BPH, Urethra & Penis Disorders, Scrotal Mass, Torsion Flashcards
Function of the prostate
- gland that makes fluid for ejaculation
- produces PSA protein
Why are glands hard to treat with antibiotic?
No blood flow
Lab to screen for prostate cancer
PSA
Causes of elevated PSA
enlarged prostate, infection, prostate cancer
Function of ejaculatory duct
carries sperm from testes
fluid from seminal vesicles and fluid from prostate
testes mainly composed of what 2 things
sperm and testosterone
vasectomy destroys what structure
vas deferens
Most common benign tumor in men
BPH
Elevated risk of BPH begins at what age?
40
Location of BPH
around urethra - transition zone of prostate
Why do rectal exam for prostate cancer?
cancer most commonly occurs in peripheral zone of prostate on rectal/posterior side
*may miss BPH
2 categories of BPH symptoms and how they are caused
obstructive - mechanical (BOO) or dynamic (adrenergic tone)
irritative - detrusor muscle hypertrophy and hyperplasia
irritative symptoms of BPH
- Increased frequency
- Urgency and difficulty postponing urination
- Discomfort when urinating
- Nocturia
obstructive symptoms of BPH
Hesitation Straining when urinating Weak or intermittent stream Sense that bladder hasn't emptied completely Dribbling
DDX of voiding complaints in males
Urethral stricture/bladder neck contracture
Urinary tract infection
Carcinoma of the bladder (hematuria resistant to abx gets urology referral)
Neurologic disease
Diabetes mellitus
suspected BPH lab work-up
serum creatinine
look for infection and hematuria
imaging of kids with UTI
< 2 yrs old
any boy
any GU anomalies
any child with recurrent (>3/yr)
Man with hematuria needs what imaging?
CT urogram
Refer to urology
Man with elevated creatinine needs what imaging?
renal/bladder US
How to manage BPH with IPSS score 0-7 (mild sx’s)?
watchful waiting
How to manage BPH with IPSS score +7 (mod to severe sx’s)?
Nonselective α-Blockers
- Terazozin (Hytrin)
Selective α1a-receptor blockers
- Tamsulosin (Flomax)
MOA of alpha blockers in BPH
relaxation of prostate smooth muscle (rich in adrenergic nerve supply)
MOA of 5α-reductase inhibitor in BPH
Blocks conversion of testosterone to dihydrotestosterone (DHT)
treats prostate epithelium
5α-reductase inhibitor rare side effects
ED, decreased libido, gynecomastia
Examples of 5α-reductase inhibitor
Dutasteride (Avodart)
Finasteride (Proscar, Propecia)
1st line therapy for BPH in man with moderate to severe symptoms
alpha blocker
Cons of 5-alpha-reductase inhibitors
need 6 month therapy to see maximum benefit
only helpful in very large prostate (> 40 cm3)
When should 5a-reductase inhibitor be added to alpha blocker in BPH therapy?
Very large palpated prostates
Hemorrhagic prostates