BPH and sexual dysfunction drugs

Question 1

doxazosin

Answer 1

cardura

Question 2

terazosin

Answer 2

hytrin

Question 3

alfuzosin

Answer 3

uroxatrol

Question 4

silodosin

Answer 4

rapaflo

Question 5

tamsulosin

Answer 5

flomax

Question 6

finasteride

Answer 6

proscar

Question 7

dutasteride

Answer 7

avodart

Question 8

tadalafil

Answer 8

cialis

Question 9

dutasteride + tamsulosin

Answer 9

jalyn

Question 10

mirabegron

Answer 10

myrbetriq

Question 11

relieve symptoms by blocking SM tension in the prostate, urethra and bladder neck

Answer 11

alpha 1 blockers

Question 12

alpha 1A receptors in

Answer 12

prostate

Question 13

alpha 1B&D rectors in

Answer 13

heart and arteries

Question 14

which alpha 1 is less likely to cause hypotension but more likely to cause ED

Answer 14

tamsulosin and silodosin

Question 15

which alpha 1 must be given at bedtime due to dizziness

Answer 15

doxazosin, terazosin, alfuzosin

Question 16

do alpha 1 blockers shrink the prostates size or change PSA levels?

Answer 16

no

Question 17

which alpha 1 leaves a ghost tablet in stool

Answer 17

cardura XL

Question 18

which alpa 1 causes retrograde ejaculation

Answer 18

silodosin

Question 19

which alpha 1 causes risk for QT prolongation

Answer 19

alfuzosin

Question 20

alpha 1 blocker ADE

Answer 20

hypotension
dizziness
fatigue
ejaculatory dysfunction
floppy iris syndrome (tamsulosin)

Question 21

works by blocking the conversion of testosterone to dihydrotestosterone

Answer 21

5 alpha reductase inhibitors

Question 22

does 5 alpha reductase inhibitors shrink the prostates size and decrease PSA levels?

Answer 22

yes

Question 23

found to cause hair growth

Answer 23

finasteride

Question 24

reserved for men with prostate >30g and takes 6 months to benefit from therapy

Answer 24

dutasteride

Question 25

can 5 alpa reductase cause sexual dysfunction even after stopping the medication?

Answer 25

yes

Question 26

5 alpha reductase inhibitors ADE

Answer 26

impotence decreased libido ejaculation disturbances breast enlargement/ tenderness (gynecomastia)

Question 27

which class of drugs cannot be handled by pregnant women and is on the NIOSH list of HD

Answer 27

5 alpha reductase inhibitors

Question 28

works to improve symptoms by causing SM relaxation in the bladder, urethra, and prostate

Answer 28

PDE5i

Question 29

what can PDE5i not be combined with

Answer 29

alpha blockers nitrates

Question 30

PDE5i contraindications and warnings

Answer 30

MI/stroke within 6 months hearing/vision loss hypotension due to vasodilation priapism (erection lasting longer than 4 hours)

Question 31

PDE5i ADE

Answer 31

HA flushing dizziness dyspepsia muscle/back pain

Question 32

stimulates the B3 receptors in the bladder that increases production of cAMP which relaxes the detrusor muscle

Answer 32

B3 agonist

Question 33

mirabegron should not used with CrCL

Answer 33

<15

Question 34

B3 ADE

Answer 34

mild HA dry mouth nausea constipation nasopharyngitis QT prolongation

Question 35

saw palmetto can reduce efficacy of what class

Answer 35

5 alpha reductase inhibitors

Question 36

test depot IM injection

Answer 36

testosterone cypionate or enanthate

Question 37

test SQ injection

Answer 37

xyosted

Question 38

test patch

Answer 38

androderm testoderm apply daily

Question 39

test topical gel

Answer 39

testim androgel fortesta

Question 40

test topical solution

Answer 40

axiron

Question 41

test implanted pellet

Answer 41

pestopel

Question 42

test buccal

Answer 42

striant

Question 43

test nasal gel

Answer 43

natesto

Question 44

test oral gel

Answer 44

jatenzo

Question 45

start of sexual dysfunction

Question 46

alprostadil

Answer 46

caverject, edex- injection MUSE- urethral pellet

Question 47

avanafil

Answer 47

stendra

Question 48

sildenafil

Answer 48

viagra

Question 49

vardenafil

Answer 49

levitra staxyn

Question 50

PDE5i counseling points

Answer 50

take with or without food no more than 1 dose recommended per day

Question 51

which PDE5i have decreased efficacy with high fat/large meals

Answer 51

sildenafil vardenafil

Question 52

take 1 hour prior

Answer 52

sildenafil vardenafil

Question 53

take 30 minutes prior

Answer 53

tadalafil

Question 54

take 15-30 minutes prior

Answer 54

avanafil

Question 55

when do you decrease the starting dose of PDE5i by 50%

Answer 55

>65 y/o using an alpha blocker using CYP3A4 inhibitor sever renal or liver disease

Question 56

PDE5i drug interactions

Answer 56

alcohol (hypotension) grapefruit juice (increase conc. of PDE5) alpha blockers CYP3A4 inhibitors (increases conc. of PDE5) CYP3A4 inducers (may need increased PDE5 dose) nitrates

Question 57

if you have to take a PDE5i and a alpha blocker what should you do

Answer 57

be stabilized on 1 before starting the other at the lowest possible dose separate admin at 4 hours

Question 58

if on PDE5i and need nitro how long separated?

Answer 58

avanafil- 12hr sildenafil and vardenafil- 24hrs tadalafil- 48hrs

Question 59

flibanserin

Answer 59

addyi oral

Question 60

bremelanotide

Answer 60

vyleesi infection

Question 61

flibanserin and bremelanotide is women HSDD in what kind of women

Answer 61

perimenopausal

Question 62

flibanserin class

Answer 62

5HT1A agonist/5HT2A antagonist

Question 63

flibanserin counseling

Answer 63

take at night to avoid daytime hypotension completely abstain from alcohol (severe hypotension) do not use with CYP3A4 inhibitors (d/c flibanserin 2 days prior and wait 2 days after d/c CYP3A4 prior)

Question 64

activates melanocortin receptors

Answer 64

bremelanotide

Question 65

bremelanotide counseling

Answer 65

take 45 minutes prior no more than 1 dose in 24 hours no more than 8 doses per month d/c after 8 weeks if no improvement

Question 66

bremelanotide contraindications

Answer 66

uncontrolled HTN CVD or high risk for CVD

Question 67

bremelanotide ADE

Answer 67

N/V flushing injection site reactions HA darkening of gums and parts of skin (face and breasts) BP elevation