Bp1

Question 1

Study of effect of drug on body

Answer 1

Pharmacodynamics

Question 2

Study of effect of body on drug

Answer 2

Pharmacokinetics

Question 3

What does pharmacodynamics allow you to determine?

Answer 3

Dosage, compare effective and safety to other drugs

Question 4

What 2 factors determine drug interactions with target?

Answer 4

Shape and charge distribution

Question 5

What does the shape of the drug determine?

Answer 5

Ability to bind

Question 6

What does the charge distribution of the drug determine?

Answer 6

Bond that forms

Question 7

Name 4 bonds between drug and target from weakest to strongest?

Answer 7

Van der waals
Hydrogen
Ionic
Covalent

Question 8

How do hydrogen bonds form?

Answer 8

H atom bound to O or N makes it more positive so it bind to other more negative atoms

Question 9

4 factors affecting bonding?

Answer 9

Hydrophobicity
Ionisation
Conformation of target
Stereoisomerisation

Question 10

4 main targets for drugs

Answer 10

Enzymes
Receptors
Ion channels
Carrier proteins

Question 11

Some drugs don’t interact with targets, how do they work?

Examples

Answer 11

By virtue of their own physicochemical properties
Laxatives = pull water into stool
Antacids = decrease pH of stomach