Adrenergic agonists and antagonists Flashcards
Where are noradrenergic receptors found?
Post-ganglionic sympathetic fibres
How is NA transmission terminated?
Re-uptake and metabolism of NA to amines using monoamine oxidases
2 types of NA receptors?
Alpha and beta
What type of receptors are adreno-receptors/NA receptors?
G coupled
What effects do alpha 1 receptors target?
Vasoconstriction to visceral organs
Where are alpha 2 receptors found? What is their function?
Pre-synaptic receptors, retake NA and inhibit release by negative feedback
Difference between auto and heteroreceptor (alpha 2)?
Autoreceptor on the same synapse as NA and inhibits release of NA from that synapse
Hetero = on another synapse - reputes NA into a different fibre and inhibits transmission of that NT
What do B1, B2, B3 receptors mediate?
B1 = Increased HR B2 = Bronchodilation B3 = Increase lipolysis
Name an alpha 1 agonist? How does it change with route of admin?
Adrenaline
Iv = alpha 1 mediated vasoconstriction (prolong LA)
IM = alpha 1 mediated vasoconstriction, B1 increase HR< B2 bronchodilation = treat anaphylactic shock
Name a selective B1 and a selective B2 agonist?
Dobutamine = increase heart rate Salbutamol = bronchodilation = treat asthma
Prazosin is an alpha 2 agonist, what is its function?
Vasodilation to visceral organs = treat hypertension
Propanol and atenolol are both used for what?
B1 mediated decrease in heart rate to treat hypertension
How are salivary glands innervated/
Direct innervations by alpha 1, Beta 1 and beta 2
How can drugs affect synthesis of NA? What is this used to treat?
False substrate
MeDOPA = decreased Na production
Treat hypertension
How does reserpine effect NA storage?
Disrupt synaptic vesicles, less Na available for release, treat hypertension
