Bowel Flashcards

1
Q

what antibiotics cause c diff (5)

A
quinilones
clindamycin
cephlasporins (second and third gen)
ampicillin/ amoxicillin
co-amox
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2
Q

antispasmodics which slow gut transit e.g. codeine are contrainditcated in diverticular disease because

A

they can exacerbate symptoms

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3
Q

what sort of fiber should people with IBS use

A

soluble - e.g. ispagula husk

not insoluble like bran

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4
Q

what sort of laxative is preffered in IBS

A

osmotic such as macrogol

but lactulose may cause bloating

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5
Q

in IBS patients who have not responded to antispasmodic drugs for abdo pain what can be tried

A

TCA

or later SSRI

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6
Q

what type of drug is mesalazine

A

aminosalicylate

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7
Q

is cuclosporin used for crohns or UC

A

UC

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8
Q

what is the connection between smoking and chrons

A

smoking cessation reduces the risk of relapse

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9
Q

What two antibiotics are used for fistulating crohns disease

A

metronidazole and cirpofloxacin

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10
Q

what is the risk of metronidazole use in fistulating crohns

what duration do we limit it to

A

peripheral neuropathy

usually 1 month, at most 3 months

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11
Q

do we use antispasmodic or antimotility drugs in IBD

A

no - may percipitate mega colon (includes loperamide, codeine etc) treatment of the inflamation is more logical

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12
Q

what is colestyramine used for in IBD

A

diarrhoea resulting from loss of bile salt absorption (as cholestytamine binds bile salts)

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13
Q

which aminosalicylate is older, activates further up the bowel and therefore has more sulfonamide like side-effects

A

sulfasalazine

as opposed to new ones: mesalazine, besalazine, osalazine

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14
Q

what significant 2 side-effectds are common to all aminosalycilates

A

blood disorders and lupus like syndrome

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15
Q

what are the sulfonamide like sideeffects of aminosalycilates

A
Diarrhea.
dizziness.
loss of appetite.
nausea or vomiting.
tiredness
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16
Q

what should always be given with methotrexate in IBD

A

folic acid on a differenty day

17
Q

patients taking aminosalicylates should be councelled to report signs of blood disorders such as

A
sore throat
fever
malaise
bruising
bleeding
18
Q

how often should renal function be monitored for aminosalicylates

A

at 3 month and then annually

19
Q

what is the caution with using lactulose with mesalazine

A

preparations that lower ph may prevent the release of drug

20
Q

which aminosalycilate has high monitoring requirements

LFTs, renal and FBC

A

sulfasalazine

21
Q

what drugs should be withheld on the day of bowel prep (3)

A

ACEi/ARB
NSAIDs
duiretics

22
Q

what class of drug is mebevarine

A

antimuscarinic

23
Q

when should mebevarine be taken

A

20 mins before meals

24
Q

what is ursodexycholic acid used for ?

A

dissolution/prophylaxis of galls stones and billary cirhosis

25
Q

how lond can orlistat be used for

A

12 months

26
Q

what is methycellulose used for but there is little evidence of benifit

A

increase satiety in obesity

27
Q

What are phentermine and diethylpropion

what are the risks

A

central stimulants NOT recommended for obesity

phentermine - pulmonary hypertension

28
Q

what would be the local aneasthetic of choice for anal fissure

what are two associated risks

A

lidocaine - others are more irritant

  • caution excessive use as absorbed through anal mucosa
  • local sensitisation after more than a few days use
29
Q

what are zinc oxide, bismuth subgallate, hamamelis used for in haemerroids

A

soothing ans astringent

30
Q

when should you use oily phenol for haemoerroids and what is the mode of administration

A

injection

mainly for unprolapsed haemerrhoids

31
Q

if you are mixing your pancreatic enzymes with food what should you do to avoid them breaking down

A

admin within the hour

avoid excessive heat

32
Q

what should you mix gastro resistant pancreatic enzymes with

A

milk, slightly acidic soft food

swallow imediately without chewing

33
Q

when should pancreatic enzymes be taken in relation to food and why

what else could you use for this effect (2 drugs)

A

with or just after as inactivated by acid

you can also give cemetidine and ranitidine with them

34
Q

why are EC and MR preps not suitable in stoma

A

not sufficient release of active ingrediant

35
Q

why should you not give enemas and washouts to patient with a stoma

A

severe loss of electrolytes and water

36
Q

if constipated what laxatives would be ok in stoma patient

A
bulk forming (can also use this to treat diahorrea weirdly)
senna
37
Q

what is the caution with antacids in stoma patients

A

tendancy increased for
Mg - diahorreah
Aluminium - constipation

38
Q

diuretics should usually be avoided in stoma but if you had to use one what would you choice

A

K sparing

39
Q

what is the risk of digoxin in stoma

A

particularly suceptable to hypokalaemia