Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Endo II > Bone Pharm > Flashcards

Bone Pharm Flashcards

1
Q

Hormones

A

Teriparatide

calcitonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Vit D

A

choecalciferol (D3)
ergocalciferol (D2)
Calcitriol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Estrogen R modulators

A

Raloxifene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bisphosphonates

A

Alendronate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MABs

A

denosumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

appendicular bone

A

80% of bone mass

mostly compact cortical bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

axial bone

A

trabecular

alteration in bone turn-over occur here

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

OPG

A

decoy R for RANKL
produced by osteoblasts
suppressed by estrogen deprivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

normal Ca

A

8.5-10.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

normal Phosphate

A

2.5-4.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PTH and bone

A 
increases activity and number of osteoclasts by binding osteoblasts which release RANKL which activates osteoclasts
inhibits sclerostin (inhibits osteoblasts) from osteocytes, but net effect is still bone break down
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PTH and kiindey

A

increase Ca resorption
increases Phosphorous excretion
sitimulates vit D activation
increases Mg resorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

teleparatide

A

synthetic recombinant human parathyroid hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

teleparatide MOA

A

continuous administration causes bone demineralization

intermittent promotes growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

uses of teleparatide

A

women w/Hx of osteoporotic fracture and failed other drug therapy
men with primary hypogonadal osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

ADRs teleparatide

A 
orthostatic hypotension
hypercalemia
dizziness, nausea
hyperuricemia
anggina
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

teleparatide CI

A

pts with increased risk of osteosarcoma: pagets, elevated alk phos, open epiphyses, prior radiation therapy of skeleton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Calcitriol actions

A

augments intestinal absorption and retention of Ca and phos
increases bone turnover by
-recruitment and activation of osteoclasts
-increasing RANKL and osteocalcin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

otherwise healthy what type of vit D do you Tx with?

A

ergocalciferol or cholecalciferol

20
Q

liver dis what type of D do you Tx with?

A

25-hydroxy

21
Q

kindey dis what type of D do you Tx with?

A

calcitriol

22
Q

what can vit D be used to Tx

A

rickets
hypoparathyroidism
prevention and Tx of osteoporosis

23
Q

ADRs to vit D

A

hypercalcemia -> n/v constipation
hyperphosphatemia
arrhythmias and pancreatitis

24
Q

FGF23

A

inhibits 1,25 (OH)2D production and phosphate resorption in kidney
produced by osteocytes and osteoblasts

25
Q

calcitonin

A

decreases serum Ca and phos
inhibits osteoclasts
decreases Ca and Phos resorption in kidney

26
Q

uses of calcitonin

A

pagets
osteoporosis
hypercalcemia

27
Q

ADRs of calcitonin

A

nausea, hand swelling, urticaria, intestinal cramping

28
Q

estrogens

A

prevent bone loss post-menopause

SERM (raloxifene) less ADRs then E

29
Q

raloxifene ADRs

A

hot flashes
leg cramps
thromboemoblism (3x increased risk)

30
Q

CI of raloxifene

A

Hx of venous thromboembolism
CAD
strokes

31
Q

bisphosphonate mOA

A

analogs of pyrophosphonate with C
chelate Ca
incorporate into bone
decrease formation and dissolution of hydroxyapatite crystals and inhibit osteoclasts

32
Q

PK of bisphosphonates

A

must be taken on empty stomach 30 min before meal

must be sitting upright and taken with full glass of water

33
Q

uses of bisphos

A

osteoporosis
hypercalcemia of malignancy
pagets

34
Q

ADRs of bisphos

A

osteonecrosis of the jaw

subtrochanteric femur fractures

35
Q

Denosumab MOA

A

binds RANKL

mimics osteoprotegrin

36
Q

PK of denosumab

A

sub-q every 6 months

37
Q

denosumab ADRs

A

possible immunosuppression
risk of osteonecoris of jaw and subtrochanteric fractures (maybe)
transietn hypocalcemia

38
Q

cincalcet MOA

A

activated CaSR -> inhibits PTH secretion

39
Q

uses of cincalcet

A

secondary hyperparathyroidism

40
Q

hypercalcemia Tx

A 
saline diuresis +/- furosemide
bisphos
calcitonin (takes 4-6hrs)
IV phosphate (fastest, but must be very careful)
glucocorticoids
41
Q

hypocalcemia Tx

A

Ca (IV, IM, or PO)
If IV Ca gluconate preferred
Vit D

42
Q

hyperphosphotemia Tx

A
  • restrict dietary phosphate
  • phosphate binding gels (Ca)
  • aboid aluminum antacids
43
Q

primary hyperparathyroidism

44
Q

secondary hyperparathyroidism

A

vit D

cinacalcet

45
Q

hypoparathyroidism

46
Q

pagets

A

calcitonin and bisphosphonates (only for 6 months at a time)

Endo II (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions