Bone Pathology Flashcards
name 5 developmental abnormalities of bone relevant to dentistry
tori
osteogenesis imperfecta
achondroplasia
osteoporosis
fibrous dysplasia
what is fibrous dysplasia
gene defect causing fibrous replacement of bone
what are two differential diagnoses for fibrous dysplasia
cemento-osseous dysplasia
paget’s disease
how is fibrous dysplasia managed
bisphosphonates
what is osteitis fibrosis cystica
caused by hyperparathyroidism - reduced serum calcium causes increased bone turnover (resorption by osteoclasts)
what is the histopathology of osteitis fibrosis cystica
mutlinucleate giant cells
extravasated erythrocytes
name two possible differential diagnoses of osteitis fibrosis cystica
peripheral giant cell granuloma
central giant cell granuloma
what is cherubism
gene defect causing multiple mulitlocular radiolucencies in the jaws
what is the histopathology of cherubism
mutlinucleate giant cells
extravasation of erythrocytes
what is a differential diagnosis of cherubism
fibrous dysplasia
what is Paget’s disease
due to osteoclast dysfunction
disorganised formation and remodelling of bone
how does Paget’s disease present radiographically
poorly defined irregular radiopacities
cotton wool appearance
loss of lamina dura
hypercementosis
ankylosis
what is a differential diagnosis of Paget’s disease
fibrous dysplasia
what is ossifying fibroma
benign bone tumour
well-defined radiolucency
demarcated transition to surrounding bone
what is cementoblastoma
benign cementum tumour
radiopaque, well defined and continuous with cementum
surrounded by radiolucency zone and loss of PDL
