Bone Mineral Homeostasis

Question 1

The two main Ions in bone mineral homeostasis

Answer 1

1. calcium
   2.phosphate

Question 2

why is the regulation of calcium and phosphate important

Answer 2

• for the health and strength of bones
  -calcium balance has significant effects on electrical excitability of cells, by bonding to membrane glycoproteins
  calcium is an essential intracellular signal that can regulate expression of many genes

Question 3

osteoblasts and osteoclasts

Answer 3

osteoblasts: deposition of bone
osteoclasts: resorption of bone

• activation of osteoclasts is indirect - the hormones activate osteoblasts, secretion of RANK ligand from osteoblasts activates osteoclasts

Question 4

teriperatide

Answer 4

synthetic PTH 1-34 marketed as a therapeutic for osteoporosis