Bone Marrow and Hematopoiesis Flashcards
What is hemopoiesis?
A general classification for all blood cell development
What are the different phases of hemopoietic development?
Yolk Sac Phase, Liver Phase and Adult Phase
What is the primary hemopoietic organ in the adult phase?
Bone marrow
How does the primary location of hemopoiesis change through the adult phase?
In early adult hood hemopoiesis is leaving long bones and moving to axial skeleton bones
What are the adult hemopoietic loci?
Myeloid (marrow) tissue, and lymphoid tissue
What is the monophyletic theory?
All blood cells arise from common stem cell
What are colony forming units?
Small lymphoid-like stem cells capable of mitosis
What kind of marrow is hemopoietically active?
Red Marrow
Why is marrow with reduced activity yellow?
Adipocytes dominate the tissue
What are the fixed cells within the connective tissue of bone marrow?
Fibroblasts, reticular cells, macrophages, adipocytes, ostoblasts, endothelial cells, etc.
What anatomic part of the bone is bone marrow located?
Medullary cavities of bone
What is the cell from which all blood cells can be derived? What two cells can it differentiate into?
Hemopoietic stem cell; common myeloid progenitor and common lymphoid progenitor
What cells can be directly produced by a common myeloid progenitor?
Granulocyte monocyte progenitor and megakaryotcyte erthyrocyte progenitor
How does a mast cell develop from the granulocyte/ monocyte progenitor?
the progenitor differntiates to a basophil/ mast cell progenitor–> mast cell progenitor–> mast cell
What is the granulocyte developmental sequence?
Myeloblast–> Promyelocyte–> myelocyte–> metamyelocyte–> band (stab) cell–>
Myeloblasts might be found in the peripheral blood in a patient with what condition?
Myelogenous leukemia
How long is development of a granulocyte? the typical lifespan of a granulocyte?
About 14 days; 1-3 days after development
What is the relative ratio of granulocyte to erythrocytes in the bone marrow? Why?
More granulocytes than erythrocytes due to the shorter lifespans of peripheral granulocytes vs. erythrocytes and longer development time for granulocytes
What does a decreased peripheral white count stimulate in the bone marrow?
Increased WBC release from marrow and increased differentiation of WBC’s from specific CFU’s
Where does lymphopoiesis occur?
Occurs in both myeloid and lymphoid tissue
What is the developmental sequence for lymphopoiesis?
Colony Factor Unit–> Lymphoblast–> Lymphocyte
What are the macrophages of the liver? of the bone?
Kupfer cells; osteoclasts
What is the developmental sequence of macrophages?
CFU–> Promonocyte–> monocyte–> macrophage
What substances will induce erythropoeisis?
Fe, B12, erythropoietin
