bone marrow

Question 1

what needs to be matched for bone marrow transplant?

Answer 1

• blood type does not matter
• HLA needs to match form class I and II
• 6 point match is perfect

Question 2

GVHD is what type of phenomenon

Answer 2

T cell

Question 3

a successful BMT will show this ratio of CD8:CD4

Answer 3

increased for 6 months

Question 4

blood profile of a newborn

Answer 4

Hg-18-20

Hct-60

Question 5

blood profile of adolescent

adult

Answer 5

11/33

15/45

Question 6

MCV adult
kid
newborn

Answer 6

87 +- 7
77/78 till puberty
98-103

Question 7

where are plasma cells?

Answer 7

in circulation, not in tissue

Question 8

ABO antigen

Answer 8

type O you have anti A and anti B
type A you have anti B
Type B you have anti A
type AB you have nothing

Question 9

donor’s red cells are screened against the pts

Answer 9

serum

Question 10

those that are chronically transfused will develop a white cell rxn. Treat these people with…

Answer 10

steroids, antihistamines

Question 11

what immunoglobulins can we get out of donated blood?

Answer 11

• zoster
• Hep B
• anti Rh

Question 12

folic acid is absorbed in the

Answer 12

upper intestine

Question 13

subacute combined degeneration of the spinal chord is a result of

Answer 13

B12 deficiency

Question 14

folic acid prevents

Answer 14

neural tube defects

Question 15

autoimmune hemolytic anemia

Answer 15

any infection or drug can cause you to make an Ab to destroy your red cells

Question 16

Lead intoxication can appear as

Answer 16

Fe deficiency

Question 17

a person with a thal trait will look like a person with

Answer 17

Fe deficiency but they have increased red counts

Question 18

what do titers measure?

Answer 18

lymphocytes in blood stream, can be inaccurate bc they go into interstitial tissue and become plasma cells

Question 19

neutrophil lifespan in periphery?

tissues?

Answer 19

10 hours

4-6 days

Question 20

when are eosinophils elevated?

Answer 20

Neoplasms
Allergy
Asthma
Cancer 
Parasite

Question 21

what is given to increase WBC production?

Answer 21

G-CSF and GM-CSF

Question 22

3 groups of receptors on phagocytes?

Answer 22

1. Adhesion molecules
2. Fc and Cb3 molecules on IgG
3. HLA I and II

Question 23

pelger-huet

Answer 23

autosomal dominant

bilobed or unsegmented neutrophils

Question 24

May-Hegglin

Answer 24

autosomal dominant
Doehle bodies
RNA segments

Question 25

Chediak Higashi syndrome

Answer 25

autosomal recessive, killer
low white count, platelets
giant granules
infection/hemorrhage

Question 26

normal absolute neutrophil count is normally

Answer 26

above 1500

Question 27

Kostman syndrome

Answer 27

congenital neutropenia
recessive, kids die form infection
marrow does not respond to G-CSF

Question 28

pt gets repeated infections over months, what could it be?

Answer 28

cyclic neutropenia, nothing wrong with their bone marrow