bone marrow Flashcards
what needs to be matched for bone marrow transplant?
- blood type does not matter
- HLA needs to match form class I and II
- 6 point match is perfect
GVHD is what type of phenomenon
T cell
a successful BMT will show this ratio of CD8:CD4
increased for 6 months
blood profile of a newborn
Hg-18-20
Hct-60
blood profile of adolescent
adult
11/33
15/45
MCV adult
kid
newborn
87 +- 7
77/78 till puberty
98-103
where are plasma cells?
in circulation, not in tissue
ABO antigen
type O you have anti A and anti B
type A you have anti B
Type B you have anti A
type AB you have nothing
donor’s red cells are screened against the pts
serum
those that are chronically transfused will develop a white cell rxn. Treat these people with…
steroids, antihistamines
what immunoglobulins can we get out of donated blood?
- zoster
- Hep B
- anti Rh
folic acid is absorbed in the
upper intestine
subacute combined degeneration of the spinal chord is a result of
B12 deficiency
folic acid prevents
neural tube defects
autoimmune hemolytic anemia
any infection or drug can cause you to make an Ab to destroy your red cells
Lead intoxication can appear as
Fe deficiency
a person with a thal trait will look like a person with
Fe deficiency but they have increased red counts
what do titers measure?
lymphocytes in blood stream, can be inaccurate bc they go into interstitial tissue and become plasma cells
neutrophil lifespan in periphery?
tissues?
10 hours
4-6 days
when are eosinophils elevated?
Neoplasms Allergy Asthma Cancer Parasite
what is given to increase WBC production?
G-CSF and GM-CSF
3 groups of receptors on phagocytes?
- Adhesion molecules
- Fc and Cb3 molecules on IgG
- HLA I and II
pelger-huet
autosomal dominant
bilobed or unsegmented neutrophils
May-Hegglin
autosomal dominant
Doehle bodies
RNA segments
Chediak Higashi syndrome
autosomal recessive, killer
low white count, platelets
giant granules
infection/hemorrhage
normal absolute neutrophil count is normally
above 1500
Kostman syndrome
congenital neutropenia
recessive, kids die form infection
marrow does not respond to G-CSF
pt gets repeated infections over months, what could it be?
cyclic neutropenia, nothing wrong with their bone marrow
