Bone Malignancies/Pediatrics Flashcards
Phases of therapeutic intervention
preventative, restorative, supportive, palliative
4 primary bone malignancies
Ewing’s sarcoma, osteosarcoma, chondrosarcoma, Malignant lymphoma of bone/parosteal osteosarcoma/periosteal sarcoma
most common place for osteosarcoma
distal femur and proximal tibia
where do tumors for Ewing’s sarcoma usually occur
LE or pelvic girdle (60%) with mets to lungs and other bones
what are the main cancers that pose a risk of metastatic disease to the bones
thyroid, breast, lung, kidney pancreas
destruction of bone by stimulated bone resorption
osteolytic
dense, new bone growth with likely lytic processes and compromised bone quality
osteoblastic
what are some of the main MS risks associated w/ met bone disease
hypercalcemia, pathologic fracture, pain, and spinal cord compression
should bed rest be prescribed to prevent pathological fracture
NO! people actually have more fx on best rest than when on therapy
characters of patients most likely to fracture
younger, greater number of sites involved w/ bony met, presence of 2 or more pathologic fractures
what is multiple myeloma
a type of leukemia that disrupts the bone remodeling process – B llymphocytes transform into malignant cells resembling plasma cells resulting in a monoclonal proliferation of plasma cells – cells accumulate in the bone marrow causing a tumor
Where does multiple myeloma stimulate lytic bone lesions most often
ribs, T-spine, pelvis, humerus, sternum, skull
equinas, varus, adduction of the foot due to fetal positioning intrauterine
talipes equinovarus (club foot)
positive barlow and ortolan tests
developmental hip dysplasia
what direction does the head/neck turn when congenital muscle torticollis occurs
lateral flexion to short side, rotation to opposite side
