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402: Rheum and derm > Bone calcification disorders > Flashcards

Bone calcification disorders Flashcards

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Dermatology Board Prep flashcards
1
Q

Medications that increase risk of osteoporosis

A

Corticosteroids

PPI

Anti-epileptics

Anti-oestrognes

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2
Q

Causes of osteoporosis

A

Low vit D/ calcium

Low peak bone density (sedentary lifestyle)

Gonadal failure

Primary hypoparathyroidism

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3
Q

Risk factors for osteoporosis [5]

A

Sedentary lifestyle

Rheumatoid arthritis

Smoking, alcohol

Low BMI

Chronic disease

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4
Q

People with osteoporosis are at risk of ______

A

Verebral fractures

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5
Q

________ is used to assess risk of fragility fracture over the next _______

A

FRAX tool= risk over 10 years.

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6
Q

Features of the FRAX tool

A

BMI

Co-morbidities

Smoking, alcohol

FHx

Bone mineral density

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7
Q

First line investigation for osteoporosis

A

DEXA scan

- Gives T score at hip

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8
Q

Osteopenia is defined as a DEXA scan T score of…

A

-1 to -2.5

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9
Q

Osteoporosis is defined as a DEXA scan T score of…

A

< -2.5

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10
Q 
Blood test findings for osteopenia would show
\_\_\_\_\_\_\_ calcium
\_\_\_\_\_\_\_ phosphate
\_\_\_\_\_\_\_ PTH
\_\_\_\_\_\_\_ vitamin D
A

Low vit D and calcium

Elevated PTH

Low phosphate

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11
Q

Lifestyle management of osteoporosis

A

Exercise- weight bearing

Smoking cessation, alcohol control

Healthy BMI

Good calcium and vit D exposure

Avoid fails with aids

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12
Q

Vitamind D and calcium supplement is indicated in osteoporosis when…

A

High risk of calcium and intake is low

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13
Q

First line pharmacological treatment of osteoporosis

A

In men, post-menopausal women

Bisphosphonates

  • 1st line = Alendronate 70mg PO OW
  • Risedronate 35mg PO OW
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14
Q

________ is a bisphosphonate not licensed in men

A

Zolendronic acid

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15
Q

Zolendronic acid is given via ______ route at _______ frequency

A

IV route, once a year.

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16
Q

Second line treatment for osteoporosis

A

Raloxifene

Stronitum ranelate

Denosumab

17
Q

Denosumab is a _______ that works by _______

A

Monoclonal antibody, inhibits RANK ligand

18
Q

__________ is indicated for severe osteoporosis with very high risk of fractures

A

Teriparatide

402: Rheum and derm (12 decks)

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