Bone bio embryo Flashcards
Bone must…
be created and maintained/repaired
respond to stress
be capable of growth
must be a living tissue
wolff’s law
since bone is metabolically expensive it will adapt to the load placed on it
-deposited where needed and resorbed where not needed
the higher the pressure to more bone deposited
bone tissue
not solid; is a matrix of composite material
the holes within matrix can be large or small
organic composite material of bone
protein-located in marrow
-collagen
resp. for elsticity and flexibility
makes up 90%
inorganic composite material of bone
mineral-gives rigidity and sturcture
made of hydroxyapatite
bone types
molecular and cellular composition is identical even when arrangement differs
compact (cortical bone)=external surface
spongy (trabecular/cancellous bone)=internal surface
osteocytes
living bone cells
regulate bone growth and chemical exchange
osteoblasts
bone building cells
secrete osteoid
when trapped they become osteocytes
osteoclasts
bone removing (cutting) cells resorb bone by recycling cellular materials
haversian system
creates bone structure, does not contain marrow and exists within the cortical section includes: -haversian lamellae -haversian canal -Volmann's canals -lacunae -canaliculi
volkmann’s canal
connects 2 haversian systems
canaliculi
connects osteocytes
haversian canal
long bone connection?
canal for blood vessel
haversian lamellae
plates that surround haversian canal and include osteocytes?
lacuna
the cavity that osteocytes sit in
osteogenesis
bone develops by replacing a preexisting connective tissue
of either membrane or cartilage
intramembranous ossification
comes from replacement of membrane connective tissue
is a process in which:
1. mesenchymal stem cells (MSC) organize
2. mesenchymal condenses into layers (membrane)
3. MSC differentiate into membrane
4. osteoblasts secrete collagen matrix (osteoid)
5. matrix mineralizes beginning at center of ossification (CO1)
6. ossification fans out from CO1
endochondral ossification
- MSC organize
- MSC differentiate into chrondrocytes (cartilage producing cells)
- chondrocytes create a cartilage model
- blood vessels pierce carilage model which brings osteoblasts to secrete osteoid which mineralizes into bone
- blood vessels then pierce both ends of the cartilage model
- osteoclasts remove bone from the center of the ossified bone shaft
- growth continues at the cartilage border between the shaft (CO1) and ends (CO2) until after puberty
interstitial bone growth
occurs at the cartilagenous plate/epiphyseal plate/ synchrondosis (in head)
resp. for growth in length
appositional bone growth
bone growth in diameter
occurs on bone surface by putting layers on the outside and then taking bone away in the middle to form a cavity
bone growth in length
interstitial bone growth
bone growth in diameter
appositional bone growth
4 sources of variation in bone growth
- ontogeny (speed of growth)
- sex (body size dimorphism)
- geography/population
- individual (gene and environment interaction)
fertilization
occurs on day 1
cleavage comes next