bone and mineral homeostasis agents

Question 1

Aspirin MOA

Answer 1

acetylation of COX-1 & COX-2, dec. in prostaglandin synthesis

Question 2

Aspirin AE

Answer 2

GI toxicity, nephrotoxicity, inc. bleeding time, hypersensitivity, coma in overdose

Question 3

Ibuprofen MOA

Answer 3

reversible inhibition of COX-1 & COX-2, dec. in prostaglandin synthesis

Question 4

Ibuprofen AE

Answer 4

GI toxicity, nephrotoxicity, hypersensitivity

Question 5

Celecoxib MOA

Answer 5

selective reversible inhibition of COX-2, dec. in prostaglandin synthesis

Question 6

Celecoxib AE

Answer 6

nephrotoxicity, hypersensitivity, less GI toxicity, greater risk of thrombosis

Question 7

Acetaminophen MOA

Answer 7

weak COX inhibitor

Question 8

Acetaminophen AE

Answer 8

hepatotoxicity

Question 9

Methotrexate MOA

Answer 9

cytotoxic to rapid dividing immune cells d/t inhibition if dihydrofolate reductase

Question 10

Methotrexate AE

Answer 10

nausea, mucosal ulcers, hematotoxicity, hepatotoxicity, teratogenicity

Question 11

Colchicine MOA

Answer 11

inhibition of microtubule assembly and LTB4 production; dec. macrophages migration

Question 12

Colchicine AE

Answer 12

diarrhea, severe liver and kidney damage

Question 13

Probenecid MOA

Answer 13

inhibition of renal reuptake of UA in proximal rubule

Question 14

Probenecid AE

Answer 14

exacerbation of acute gout (prevent by co-ad w/ colchicine or indomethacin)

Question 15

Allopurinol MOA

Answer 15

active metabolite irreversibly inhibits xanthine oxidase and lowers production of UA

Question 16

Allopurinol AE

Answer 16

GI upset, hypersensitivity, BM suppression

Question 17

Drug used in mgmt of jRA but not in GA since it prevents excretion of UA

Answer 17

aspirin

Question 18

associated with reye sundrome

Answer 18

aspirin

Question 19

antidote to paracetamol overdose

Answer 19

N-acetylcysteine

Question 20

toxic dose and lethal dose of paracetamol

Answer 20

t: 150mg/kg (21x500mg tabs)
l: 15g (30x500mg tabs)

Question 21

drug that inhibit secretion of other weak acids

Answer 21

probenecid

Question 22

first line for chronic gout

Answer 22

allopurinol