Bone and Joint Antibiotics Flashcards
1
Q
Diabetic foot infection
(Superficial)
A
- Clindamycin 450mg PO q8hrs daily x 14 days OR
- TMP/SMX 2DS tabs PO q12hrs daily x 14 days OR
- Doxycycline 100mg PO q12hrs daily x 14 days
2
Q
Diabetic foot infection with prior Abx treatment
A
- Amoxicillin/Clavulanate 875/125mg PO q12hrs + TMP/SMX 2DS tabs PO q12hrs daily x 14 days OR
- Clindamycin 450mg PO q8hrs + Ciprofloxacin 750mg PO q12hrs x 14 days
3
Q
Diabetic foot infection with Inpatient Treatment
A
- Vancomycin 15-20mg/kg IV q12hrs plus
- Ampicillin/Sulbactam 3g IV q6hrs OR
- Piperacillin/Tazobactam 4.5g IV q8hrs OR
- Ticarcillin/Clavulanate 3.1g IV q8hrs OR
- Imipenem 500mg IV q6hrs OR
- Metronidazole 500mg IV q8hrs PLUS
- Cefepime 2g IV q12hrs OR
- Ciprofloxacin 400mg IV q12hrs OR
- Aztreonam 2g IV q8hrs
4
Q
Diskitis/Osteomyelitis
A
Inpatient Therapy
- Vancomycin 15-20 mg/kg IV BID PLUS any of the following:
- Ceftriaxone 2g IV daily
- Cefepime 2g IV IV three times daily
- Ceftazidime 2g IV three times daily
- Ciprofloxacin 400mg IV three times daily
Use cefepime or ciprofloxacin if targeting Pseudomonas spp
5
Q
Felon
A
- Cephalexin 500mg PO q6hrs daily x 7 days
- TMP/SMX 2 DS tablets PO q12hrs x 7 days
- Clindamycin 450mg PO q8hrs x 7 days
- Dicloxacillin 250mg PO q6hrs daily x 7 days
6
Q
Infectious Tenosyvitis
A
Treatment should cover S. aureus, Streptococcus, and MRSA
- Vancomycin 25-30 mg/kg IV loading dose then 15-20mg/kg IV q12hrs PLUS
- Levofloxacin 750 mg IV once daily (avoid in pediatrics) OR
- Ceftriaxone 1g IV daily
- If suspicious of Gonococcal infection then use Ceftriaxone 1g IV once daily AND Chlamydia coverage with
- Azithromycin 1g PO once OR
- Doxycycline 100mg PO twice daily
7
Q
Grade I/II Open fracture
A
- 1st generation cephalosporin: e.g. Cefazolin (Ancef) 2g IV TID
- Allergy to above: Clindamycin or vancomycin (25mg/kg) IV
8
Q
Grade III Fracture open
A
- 1st generation cephalosporin: e.g. Cefazolin (Ancef) 2g IV TID
- Allergy to above: Clindamycin or vancomycin (25mg/kg) IV
- Gentamycin 300mg IV (1-1.7mg/kg)
9
Q
Gonococcal Septic Arthritis
A
- Ceftriaxone 1 g IV daily
- Cefixime 400mg PO BID for outpatient therapy.
10
Q
Non-Gonococcal Septic Arthritis
A
- Vancomycin 15-20mg/kg IV BID. PLUS
- Ceftiaxone 2g IV.
- Cefepime 2g IV TID
- Ceftazidime 2g IV TID
- Ciprofloxacin 400mg IV TID.
11
Q
Septic Bursitis
(outpatient)
A
- Clindamycin 300 mg PO three times daily x 14 days OR
- TMP/SMX 2 DS tabs PO two times daily x 14 days OR
- Dicloxacillin 500mg PO q6hr x10 days
12
Q
Septic Bursitis
(inpatient)
A
- Vancomycin 25-30 mg/kg IV loading then 15-20 mg/kg IV OR
- Clindamycin 600 mg (10/mg/kg) IV three times daily
- Linezolid 600 mg IV BID (10mg/kg Q8hrs for pediatrics)
