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PHARM.M2.Neuromuscular Relaxants > BOLDED DRUGS > Flashcards

BOLDED DRUGS Flashcards

1
Q

SUCCINYCHOLINE

A

duration of action:

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2
Q

PANCURONIUM

A

duration of action: 30-60 min
Mech of action: NON-depolarizing blockade of muscle nicky R
Elimination: primarily renal excretion
Rx: adjuvant in surgical anesthesia, sp. abdominal wall relaxation and ortho procedures

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3
Q

D-TUBOCARARINE

A

duration of action: >60 min
Mech of action: non-depolarizing blockade of muscle nicky R
Elimination: liver clearance and renal elimination
Rx:PROTOTYPE only used in lethal injection

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4
Q

ROCURONIUM

A

duration of action:~25 mins
Mech of action: non-depolarizing blockade of muscle nicky R
Elimination:liver
Rx: intubation, muscle relaxation during surgery or ventilation

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5
Q

MIVACURIUM

A

duration of action: 15-20 mins
Mech of action:non-depolarizing blockade of muscle nicky R
Elimination: plasma ChE
Rx:intubation, muscle relaxation during surgery or ventilation in pts with renal failure

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6
Q

VECURONIUM

A

duration of action:
Mech of action:non-depolarizing blockade of muscle nicky R
Elimination: liver metab and clearance, renal elimination
Rx: adjuvant in surgical anesthesia, sp. abdominal wall relaxation and ortho procedures

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7
Q

BACLOFEN

A

duration of action: (1.5hrs)
Mech of action: inhibits NT release from skeletal.mu sensory afferent
Elimination: (urine)
Rx:muscle spasticity associated with NS or spinal cord injury

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8
Q

DIAZEPAM

A

duration of action: (43 hr)
Mech of action: benzodiazepine receptor agonist
Elimination: (liver)
Rx: muscle spasm due to local injury (inflammation), muscle spasticity due to loss of descending inhibitory input (e.g. cerebral palsy)

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9
Q

TIZANIDINE

A

duration of action: (2.5hr)
Mech of action: centrally acting alpha TW agonist
Elimination: (liver)
Rx: muscle spasticity due to spinal cord injury or MS

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10
Q

DANTROLENE

A

duration of action: (8hr)
Mech of action: uncouples excitation-contraction of skeletal mu (blocks ryanodine receptor)
Elimination:–
Rx: muscle spasm, malignant hyperthermia

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PHARM.M2.Neuromuscular Relaxants (3 decks)

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