Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Mercy CLS 7/8: Coagulation/Body Fluids > Body fluids—CSF > Flashcards

Body fluids—CSF Flashcards

1
Q

functions of CSF

A
  • supplies nutrients to nervous tissue
  • removes metabolic wastes
  • produces mechanical barrier to cushion CNS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 layers that line CNS

A

meninges
- dura mater
- arachnoid mater
- pia mater

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

space where CSF flows

A

subarachnoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

produce CSF

A

choroid plexuses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

—- mL/hour of CSF is produced

A

20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

2 processes that contribute to CSF production

A
  1. filtration under hydrostatic pressure across capillaries of choroid plexuses
  2. active transport secretion by choroid epithelial cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

reabsorb CSF, regulating CSF pressure and volume

A

arachnoid villi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

total volume CSF

A

adults: 140-170 mL
neonates: 10-60 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

control and filtration of blood
bidirectional transport

A

blood brain barrier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

lumbar puncture occurs where?

A

between 3rd, 4th or 5th vertebrae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

where do CSF tubes go?

A
  1. chemistry/serology
  2. micro/PCR
  3. hematology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CSF sample handling & storage

A

highly contagious
never spin uncapped

Storage
chem/sero: freeze
micro: RT
heme: refrigerate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

can remove up to —- mL CSF on an adult

A

20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ways to describe CSF appearance

A
  • crystal clear
  • cloudy
  • turbid
  • milky
  • xanthochromic
  • hemolyzed/bloody
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

causes of turbid CSF

A
  • protein
  • lipid
  • infection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

causes of xanthochromic CSF

A

pink, orange or yellow
- RBC degradation products
- serum bilirubin (prematures)
- carotene
- high protein
- melanoma pigment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

CNS production of IgG indicates…

A

MS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

causes of bloody CSF

A
  • subarachnoid hemorrhage
  • traumatic tap
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

how to distinguish traumatic tap from subarachnoid hemorrhage?

A
  • distribution of blood (equal in all tubes or decreases)
  • clot formation (traumatic)
  • xanthochromic supernatant (hemorrhage)
  • macrophages with RBCs, hemosiderin (hemorrhage)
20
Q

RBCs begin to lyse in CSF within…
—–% WBCs will lyse within 2 hours

A

1 hour
40

21
Q

for a proper CSF dilution, ——- cells/large square should be seen

A

10-100

22
Q

if <—– cells are counted in CSF, count more squares

A

40

23
Q

RBCs in CSF can be lysed with…

A

3% acetic acid

24
Q

concentrates cells in CSF for a diff

A

cytocentrifugation

25
Q

add ——— during cytocentrifugation to keep cells intact

A

1 drop albumin

26
Q

distortions common in cytocentrifuged CSF specimen

A
  • vacuoles
  • misshapen nuclei
  • prominent nucleoli
  • cell clumping
  • pyknotics
27
Q

QC for CSF albumin

A

periodically
0.2 mL saline + 2 drops albumin
check for bacteria

28
Q

QC for CSF diluents

A

daily
fill chamber with each diluent
check for bacteria/cells

29
Q

normal WBCs found in CSF

A

lymphs and monos

lymphs more in adults, monos more in children

30
Q

increased number of normal cells in CSF

A

pleocytosis

31
Q

plasma cells in CSF

A

MS

32
Q

↑ WBC + high neuts in CSF

A

bacterial meningitis

33
Q

↑ WBC + high lymphs/monos

A

viral, tubercular, fungal or parasitic meningitis

34
Q

—— are seen in early stages of viral meningitis

A

↑ neuts

35
Q

mod ↑ WBC + reactive lymphs + plasma cells in CSF

A

neurodegenerative disease/MS

36
Q

↑ eos in CSF

A

parasitic or fungal infection
Coccidioides immitis
meds or shunts into CSF

37
Q

macrophages appear ——– after RBCs enter CSF

A

2-4 hours

38
Q

may be present in macrophages after subarachnoid hemorrhage

A
  • RBCs
  • hemosiderin
  • hematoidin crystals
39
Q
A

hematoidin crystals in CSF macros

40
Q

normal cells in CSF, not clinically significant

A
  • ependymal cells
  • choroid plexus cells
  • spindle shaped cells
41
Q

cells from arachnoid lining that may show up in CSF after procedures/neurosurgery

A

spindle shaped cells

42
Q

nrbcs in CSF

A

BM contamination or newborn with traumatic tap

43
Q

nrbcs + immature whites in CSF

A

BM contamination

44
Q

blasts in CSF

A

complication of ALL

45
Q

CSF cells with fused membranes, irregularities, hyperchromic nuclei, mitotic cells

A

metastatic carcinoma cells

Mercy CLS 7/8: Coagulation/Body Fluids (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions