Body Fluids And Circulation Flashcards
Plasma is ___ % and formed elements ___% of the blood
55
45
Colour of plasma
Straw coloured
Plasma has ___ % water and ___ % of proteins
90-92
6-8
Proteins in blood and their function
Fibrinogen - clotting factor
Albumins - maintaining osmotic balance
Globulins - defence mechanisms
Where is fibrinogen produced
Liver
Clotting factors present in plasma in what form
Inactive
Which are the most abundant formed elements in blood
Erythrocytes (rbc)
Average rbcs in healthy man
5 to 5.5 million per mm^3
RBC is formed where in adults
Red bone marrow
RBC is formed where in embryo
Yolk sac
RBCs contain ___ which is ___ in colour and contains ___
Haemoglobin
Red
Iron
Function of RBC (haemoglobin)
Transport of respiratory gases
Life span of RBS
120 days
Where are RBCs destroyed (graveyard of RBC)
Spleen
Which organelles do RBCs lack
Nucleus
Mitochondria
Number of WBC in blood
6000 to 8000 per mm^3
Types of WBCs
Granulocytes
Agranulocytes
Types of Granulocytes
Eosinophils
Neutrophils
Basophils
Types of Agranulocytes
Lymphocytes
Monocytes
Most abundant WBC
Neutrophils - 60-65 percent
Least abundant WBC
Basophils - 0.5 to 1 percent
Phagocytic WBCs are
Neutrophils and Monocytes
Basophils secrete ___ , _____ & ____ and are involved in _____ reactions
Histamine
Serotonin
Heparin
Inflammatory
Neutrophils %
60-65 %
WBC involved in anti allergic reactions and resist infections
Eosinophils
% of Eosinophils
2-3
% of Lymphocytes
20-25
Lymphocytes are of ___ & ___ types and are responsible for ___ responses of the body
B
T
Immune
Thrombocytes are ___ produced from ___
cell fragments
Megakaryocytes
No of thombocytes in blood
150,000 to 400,000 per mm^3
Mismatched blood transfusion leads to
Severe clumping of ( destruction of RBCs)
ABO grouping is based on
Surface antigens on RBCs
AB-
O-
Universal recipient
Universal donor
Rh antigen is observed on __% of humans
Nearly 80
An Rh -ve blood when exposed Rh +ve, blood will form_____
specific antibodies against the Rh antigens
A special case of RH incompatibility has been observed between the RH ___ blood of a pregnant mother with RH ___ blood of the fetus
negative
positive
Rh incompatibility between pregnant mother and foetus results in ___or ___to the baby
Severe anaemia
Jaundice
Special case of Rh incompatibility between pregnant mother and fetus is called as___
Erythroblastosis foetalis
Clot or coagulum is formed of a network of threads called____ along with ________ trapped in it
Fibrins
Formed elements
Prothrombin in converted to ____ by _______ enzyme complex
Thrombin
Thrombokinase
Thrombin converts ____ into ____
Fibrinogens
Fibrins
Coagulation of blood is a _____ process
Cascade
___ ions play important role in blood clotting
Calcium
____ has same mineral distribution as plasma
interstitial or tissue fluid
Exchange of nutrients , gases etc. b/w blood and tissue takes place through ____
Interstitial or tissue fluid
Lymph is a ____ fluid containing specialised ____ which are responsible for immune responses
colourless
lymphocytes
Closed circulation is present in ?
Annelids and Chordates
Open circulation is present in
Arthropods and molluscs
Fishes have ___ chambered hearts
2
Reptiles and amphibians (except crocodiles) have ___ heart with ___ atria and ____ ventricles
3 chambered
2
1
Birds mammals and crocodiles have ___ heart
Four Chambered
Fishes have ____ circulations
Single
Amphibians and reptiles have _____ circulations
Incomplete double circulations
In which animals do the deoxy and oxy blood get mixed
Amphibians and reptiles
Mammals and birds have _____ circulations
Double
Human circulatory system , is also called?
Blood vascular system
Heart is a ____ derived organ
Mesodermally
The heart is tilted slightly to the ____ side
left
Heart is enclosed by a _____ walled membranous bag , called _______
double
pericardium
The atrium and ventricle of the same side are separated by a thick ___ tissue called the______
Fibrous
Atrio-ventricular septum
Opening between:
left ventricle and left atrium-
Right ventricle and right atrium-
Bicuspid or mitral valve
tricuspid
Opening of right ventricle into the ____
And opening of left ventricle into the _____ are provided with _____valves
Pulmonary artery
Aorta
semilunar valves
SAN location
Right upper corner of the right atrium 
AVN location
Lower left corner of the right atrium close to the atrio-ventricular septum
The bundle of nodal fibres that arise from AV node are called what?
AV bundle
The AV bundle divides and gives rise to minute fibres throughout the _____musculature called ______ fibres
Ventricular
Purkinje
Nodal musculature in the heart is what?
Auto excitable 
Which node generates the maximum number of action potentials and how much?
SA node
70-75 per minute
The responsibility for initiating and maintaining rhythmic contractile activity of the heart is of
Sino atrial node 
relaxed state of heart chamber/s -
Contracted state of heart chamber-
Diastole
systole
_____ systole increases the flow of blood into the ventricles by about _____%,
Atrial
30
Duration of each cardiac cycle is
0.8 seconds
Each ventricle pumps out about ____ml of blood every cardiac cycle which is called____
70
Stroke Volume
Average cardiac output is?
5 L
The first heart sound …. is associated with the closure of the ….and the …. valves whereas the second heart sound …. is associated with the closure of the ….valves
lub
Tricuspid
Bicuspid
Dub
Semilunar valves
ECG:
machine-
Result -
Electrocardiograph
Electrocardiogram
P-wave represents what?
P wave represents the electrical excitation or Depolarisation of the atria that is contraction of both the atria.
What does the QRS complex represent?
The QRS complex represents the Depolarisation of the ventricles, which initiates ventricular contraction
The T wave represents the return of the …. from …. to …. state that is ….
Ventricles
Excited
Normal
Repolarisation
Pathway of Pulmonary circulation
Right ventricle (Deoxygenated Blood) - pulmonary artery - lungs - oxygenates - pulmonary vein - Left atrium
Basically, each artery and vein consists of three layers: an inner lining of……….., the tunica………, a middle layer of …….. and ……. , the tunica……., and an external layer of ………….., the tunica externa.
squamous endothelium
intima
smooth muscle
elastic fibres
media
fibrous connective tissue with collagen fibres
Pathway of systemic circulation
Left Ventricle (Oxygenated blood ) - Aorta - Arteries - Arterioles - Capillaries- Venules - Veins - Vena Cava - Right Atrium
A unique vascular connection exists between the intestine and liver called?
Hepatic portal system
What system is present in our body exclusively for circulation of blood and from the cardiac musculature.
Coronary System of blood vessels
The heart is auto regulated by specialised muscle in the heart called?
Nodal tissue
The heart is auto regulated and hence is also also called
Myogenic
The Heart is regulated by which part of the neural system
Autonomic nervous system
The sympathetic neural signal can alter the heart rate in what way and how
Increase rate of heart beat and increase strength of ventricular contraction
Thus increase Cardiac Output
The parasympathetic nervous system alters the cardiac output in what way and how?
Decreases rate of heartbeat and reduces the speed of conduction of action potential
Thus decreases cardiac output
Adrenal medullary hormones can alter the cardiac output in what way
Increases Cardiac output
Normal blood pressure
120/80
130/ 75 - in this:
130 represents what
75 represents what
130 present systolic or pumping pressure
75 represents diastolic or resting pressure
A person is diagnosed with high blood pressure when
Repeated checks of blood pressure shows 140/90 or higher
High blood pressure or hypertension leads to
Heart diseases and affects vital organs like brain and kidneys
What is heart attack
It is sudden damage caused to heart muscles due to inadequate supply of blood to it
Heart attack is also known as
Myocardial Infarction
What is Cardiac Arrest
When the heart suddenly stops beating
What is Heart Failure
It is when the heart is not able to pump enough blood to reach the needs of the body
Explain coronary artery disease (CAD)
Caused due to deposition of calcium , fat ,cholesterol and fibrous tissue in the coronary arteries that is arteries that supply blood to the heart.
This leads to narrowing of the lumen of coronary arteries
Coronary artery disease is also known
Atherosclerosis
Heart failure is also known as congestive heart failure because of?
It is also known as congestive heart failure because one of the main symptoms of heart failure is congestion of lungs
What is angina pectoris or angina?
It is acute chest pain caused due to inadequate supply of oxygen to heart muscles
Angina occurs due to
Conditions that affect the blood flow to heart muscles
Angina is more common than what people
It is more common in middle and elderly people