Body fluids Flashcards
What are the normal ranges of of NA and K extracellularly or interstitial
NA= 135-145 mM K= 3.5-5.0 mM
What is the normal body what us bodies osmolality
300 mOsm/kg
What is osmotic pressure?
Amount of pressure needed in a compartment to stop the osmotic flow of water into the compartment (no flux)
What direction does water move?
Towards the area with more particles / less water
What area has a higher osmotic Pressure
The area with the most particles
Non permeant solutes?
will only have an osmotic effect if they do not leave compartment EX: Na
also called effective osmole.
What are Permanent Solutes?
Called in ineffective osmole. it diffuses across the membrane and the osmotic gradient will eventually dissipate. There is no long term effects of ineffective osmoles so they do not change osmolarity.
EX: urea in RBCs/
After Equilibration occurs permanent solutes does not alter a cell
If we Gain Isotonic fluid what happens to cell
IV saline infusion
TBW INCREASES
ECF volume INCREASES
NO change in ICF volume or ECF and ICF osmolality
If we lose isotonic fluid what happens to cell (Loss isotonic urine via kidneys)
Decrease in TBW and ECF volume
No change in ICF volume
No change in ECF and ICF osmolarity
Gain of Pure water(hypotonic fluid) what happens to cell?
Increase TBW
Increase in ECF and ICF volume
Decrease in ECF and ICF osmolarity
Cell osmolarity is now at 294 mosm/L
Loss of hypotonic fluid( Sweating, diabetes insipidus)
Decrease in TBW
Decrease in ECF and ICF volume
Increase in ECF and ICF osmolarity
Cell osmolarity is now at 307 mOsm/L
Adding isotonic Glucose (D5W)
Increase in the volume of ECF and ICF
Decrease in Osmolality of ECF and ICF
what does the Addition of NaCl (ingestion) do to the cell?
No change in TBW INCREASE in ECF volume and osmolarity Decrease in ICF volume Increase in ICF osmolarity osmolarity of cell os now at 307 mOsm/L
What does the loss of NaCl do to the cell?
No change in TBW
DECREASE in ECF volume and osmolality
Increase in ICF volume
Decrease in ICF osmolality
What are examples of isotonic solutions?
what are they used to treat?
0.9% NaCL
Lactated Ringers- used to treat hypovolemia, burns, diarrhea
