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Dermpath > Bodies / Cells > Flashcards

Bodies / Cells Flashcards

1
Q

Antoni A Body

A

Cellular area of schwannomas; abundant Verocay bodies

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2
Q

Antoni B Body

A

HypOcellular area of schwannomas; loose myxoid stroma and low cellularity

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3
Q

Asteroid Bodies

A

Star-shaped, eosinophilic intracytoplasmic inclusions; a/w sarcoid & granulomatous dz

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4
Q

Balloon Cells

A

Clear-appearing cells w/vesicular cytoplasm, small hypERchromatic nucleus w/pseudonuclear inclusions; a/w balloon cell nevus/melanoma

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5
Q

Banana Bodies

A

Crescentic golden yellow-brown (ochre) fibers in dermis; a/w ochronosis (endogenous / homogentisic acid > exogenous / hydroquinone)

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6
Q

Bean Bag Cells

A

Histiocytes that have engulfed WBCs, RBCs, and nuclear debris (cytophagocytosis); a/w cytophagic histiocytic panniculitis, SPTCL, HLH, lupus profundus

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7
Q

Birbeck Granules

A

Only seen on electron microscopy; tennis racket structures / rods; Pathognomonic for Langerhans cells and LCH cells. NB: Langerin (CD207) is major component of Birbeck granules → Langerin immunostain most specific (> CD1a) for LCH/Langerhans cells

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8
Q

Caterpillar Bodies

A

Eosinophilic, comprised of BMZ material (PAS+, collagen 4+), in roof of blisters and basal layer of epi; a/w PCT, EPP. NB: made of the same material as Kamino bodies (Spitz nevi)

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9
Q

Cholesterol Clefts

A

Elongated, needle-shaped clear spaces once occupied by cholesterol (removed by paraffin embedding); w/i adipocytes (radiating pattern): SQ fat necrosis of newborn, sclerema neonatorum, poststeroid panniculitis; w/i dermis: NXG (> NLD), plane/eruptive xanthoma; w/i arterioles: cholesterol embolism (fibrin thrombus surrounds cholesterol)

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10
Q

Cigar bodies

A

Oval yeast (PAS+ and GMS+). a/w sporotrichosis. May also see “sporothrix asteroid” bodies = yeast with radiating pink hyaline material (immune complexes on yeast surface)

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11
Q

Civatte / Colloid / Cytoid Bodies

A

Apoptotic keratinocytes (eosinophilic); a/w LP, interface dermatitis

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12
Q

Clover Leaf Cells

A

Atypical T-lymphocytes with a cloverleaf or flower-like nucleus; seen in peripheral blood; pathognomonic for HTLV-induced adult T cell lymphoma

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13
Q

Comma-shaped bodies

A

Comma-shaped electron dense membranes seen within histiocytes (electron microscopy); Classically a/w benign cephalic histiocytosis but also JXG

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14
Q

Corps ronds

A

single or grouped, round keratinocytes w/perinuclear halo, brightly eosinophilic cytoplasm, pyknotic nucleus; in spinous layer > corneum; a/w Darier’s, warty dyskeratoma, Grover’s, Hailey-Hailey, acantholytic dyskeratotic acanthoma (trunk #1 site), papular acantholytic dyskeratosis (multiple lesions on vulva, mistaken for condyloma), PRP (focally)

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15
Q

Grains

A

smaller, flattened keratinocytes resembling parakeratosis; in granular layer/corneum; a/w Darier’s, warty dyskeratoma, Grover’s, Hailey-Hailey, acantholytic dyskeratotic acanthoma (trunk #1 site), papular acantholytic dyskeratosis (multiple lesions on vulva, mistaken for condyloma), PRP (focally)

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16
Q

Cowdry A Body

A

Intranuclear inclusions (eosinophilic globules) surrounded by halo; a/w HSV, VZV, CMV (“owl’s eye” endothelial cells)

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17
Q

Cowdry B body

A

Intranuclear inclusions; a/w poliovirus > adenovirus

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18
Q

Donovan Bodies

A

Intracytoplasmic “safety pin”-shaped bacteria in macrophages; a/w Granuloma inguinale

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19
Q

Dutcher body

A

Pseudo-intranuclear pink mass of immunoglobulins within plasma cells; Classically a/w malignant B-cells: B-cell lymphoma, multiple myeloma, Waldenstrom’s

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20
Q

Flame figures

A

Major basic protein from eosinophils deposited on collagen; a/w Wells syndrome, dermal hypersensitivity, BP (rarely). Note: Neutrophilic processes (PNGD, RA) can have bluish-purple “flame figure-like” structures from neutrophilic debris deposited on collagen

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21
Q

Floret cells

A

Multinucleated giant cells with peripherally located overlapping nuclei (resembles a flower) and “smudgy”/ indistinct chromatin; a/w pleomorphic lipoma

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22
Q

Gamma-Favre Body

A

Intracytoplasmic basophilic inclusions within endothelial cells; a/w LGV

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23
Q

Gaucher Cells

A

Glucocerebroside-laden histiocytes (“crinkled tissue paper-like histiocytes”); a/w Gaucher’s disease

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24
Q

Ghost / shadow cells (keratinized)

A

Anucleate, eosinophilic, keratinized cells with ghost-like outline where the nucleus previously resided; often surrounded by transitional cells and basaloid cells; a/w pilomatricoma, pilar cyst

25
Q

Ghost cells (lipocytes)

A

Blue-purple calcium outlines remnants of necrotic lipocytes; a/w pancreatic panniculitis

26
Q

Globi

A

Amphophilic, encapsulated collections of mycobacteria; a/w lepromatous leprosy
Other leprosy buzzword: Virchow cells (pale, foamy histiocytes parasitized by M. leprae)

27
Q

Glomus bodies

A

Specialized AV shunts that bypass capillaries; mostly on fingers / toes; temperature regulation; a/w Glomus tumor: solid nodular proliferation of glomus cells; and glomangiomas: ectatic vascular malformation w/ fewer glomus cells than glomus tumor; widespread anatomic distribution

28
Q

Guarnieri body

A

Eosinophilic cytoplasmic inclusions; a/w smallpox

29
Q

Hallmark (horseshoe) cells

A

Markedly atypical, large T-lymphs w/horseshoe-shaped nucleus; ALCL and LyP

30
Q

Henderson-Paterson Bodies

A

Pink intracytoplasmic inclusions a/w molluscum

31
Q

Kamino Bodies

A

Collections of amorphous eosinophilic/hyaline BMZ material (PAS+, collagen IV+) in tips of dermal papillae and w/i epidermis; a/w Spitz nevi; NOT seen in melanoma

32
Q

Koilocytes

A

Keratinocytes w/ viral cytopathic changes (perinuclear halo, shrunken hyperchromatic nucleus, irregular nuclear contours); a/w HPV (may just see vacuolated keratinocytes + coarse keratohyaline granules)

33
Q

Langhans giant cells

A

Histiocytic giant cells with a peripheral (“horse-shoe”) arrangement of nuclei; Classically a/w TB, but often seen in sarcoidosis and other granulomatous dz. [Not to be confused with LangERhans cells!]

34
Q

Mariner’s wheel

A

Central round yeast (60 µm) w/ multiple radiating buds; a/w Paracoccidioidomycosis

35
Q

Max-Jospeh spaces

A

Focal clefts at DEJ formed by extreme damage to basal layer from interface dermatitis; a/w LP (or, if very exaggerated, bullous LP)

36
Q

Medlar bodies

A

Thick-walled clusters of brown round yeast forms (“copper pennies”); a/w chromomycosis. ddx: pigmented hyphae seen in phaeohyphomycosis

37
Q

Michaelis-Gutmann body

A

Round, calcified, and laminated bacterial remnants; a/w malakoplakia

38
Q

Miescher’s radial granuloma

A

Small granuloma comprised of radially arrayed histiocytes around a central cleft located in fat septae; a/w erythema nodosum. [Do not confuse with “Miescher’s granuloma,” aka actinic granuloma of O’Brien, or annular elastolytic giant cell granuloma]

39
Q

Mikulicz cells

A

Foamy histiocytes containing gram negative rods (klebsiella rhinoscleromatis); a/w rhinoscleroma. [Other rhinoscleroma buzzword: Russell bodies.]

40
Q

Mulberry Cells

A

Large pink/red fat cells w/central nucleus (vs normal peripheral) and multi-vacuolated, granular, eosinophilic cytoplasm; a/w Hibernoma [tumor of brown fat; most common in adults on neck / upper back]

41
Q

Morula

A

Organism (2–11 µm) with numerous internal septations; appears similar to morula stage of embryogenesis or like “soccer ball”; PAS+ and GMS+; a/w Protothecosis (achloric alga)

42
Q

Negri body

A

neuronal inclusion a/w rabies

43
Q

Odland / lamellar bodies

A

Oval granules w/ lamellar organization seen on EM; contain phospholipids, glycoproteins, acid phosphatases; found in upper spinous and granular layers; major role in barrier fcn, keratinocyte cohesion; a/w Harlequin fetus (absent), Flegel’s disease (decreased or absent)

44
Q

papillary mesenchymal bodies

A

Condensed clusters of fibroblasts adjacent to basaloid epithelial follicular buds; recapitulates appearance of normal hair bulb (dermal papilla-hair matrix); a/w Trichoep, desmoplastic trichoep, and trichoblastoma. [Absent in BCC.]

45
Q

psammoma body

A

Concentric, calcified laminated spheres a/w Meningioma, mesothelioma, ovarian cancer, papillary thyroid cancer, and ovarian cancer

46
Q

Pustulo-ovoid bodies of Milian

A

Round eosinophilic cytoplasmic inclusions comprised of lysosomes/Golgi material (PAS+, diastase-resistant), a/w granular cell tumor

47
Q

Reed-Sternberg Cells

A

Large atypical lymphoid cells derived from germinal center B-cells; characteristic bilobed nucleus w/prominent central nucleolus giving “owl eye” appearance; CD30+, CD15+, PAX-5+ (B-cell origin); a/w Hodgkin lymphoma

48
Q

Reed-Sternberg-like cells

A

Similar to Reed-Sternberg cells on H&E, but are T-cells; CD3+, CD4+, CD30+, CD15-; a/w LyP, ALCL

49
Q

Rocha-Lima bodies

A

intracytoplasmic inclusions w/i endothelial cells; a/w Oroya fever, verruga peruana

50
Q

Russell bodies

A

Intracytoplasmic IG collections (eosinophilic) stuffing cytoplasm of plasma cells; a/w Rhinoscleroma, Granuloma inguinale. [classically a/w benign dx (“happy, pregnant plasma cells”) vs malignant assoc. Dutcher bodies.]

51
Q

Schaumann bodies

A

Calcified laminated collections a/w sarcoid

52
Q

Sezary cells

A

Atypical lymphocytes with cerebriform nuclei a/w MF, sezary syndrome

53
Q

Signet ring cells

A

Cell with eccentric nucleus and large pool of intracytoplasmic mucin (pushes nucleus to periphery); a/w any mucin-producing adenocarcinoma (usually metastatic in skin)

54
Q

Sunburn cells

A

Dyskeratotic keratinocytes scattered in upper and mid-epidermis (> basal layer); a/w sunburns, phototoxic drug

55
Q

Touton giant cells

A

Large, multinucleated histiocytes w/wreath-like nuclei and peripheral cytoplasmic lipid; a/w JXG (and other xanthomas), dermatofibroma (often contain hemosiderin. [Note: ubiquitous in DF, but not seen in DFSP!]

56
Q

Verocay bodies

A

Two stacked rows of elongated palisading nuclei surrounding amorphous pink material (cytoplasmic processes of Schwann cells); seen in hypercellular / Antoni A areas of schwannomas

57
Q

Virchow cells

A

Foamy histiocytes parasitized by acid fast bacilli; a/w Lepromatous leprosy. [Other boards buzzword: globi – encapsulated amphophilic masses of M. leprae]

58
Q

Von Hansemann cells

A

Large histiocytes w/granular eosinophilic cytoplasm containing Michaelis-Gutmann bodies; a/w malakoplakia

59
Q

Weibel-Palade Bodies

A

Cytoplasmic organelle of endothelial cells seen only with EM; contains vWF and P-selectin; von Willebrand disease is caused by qualitative or quantitative vWF deficiency

Dermpath (4 decks)

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