BOC (Immunology)

Question 1

What type of immunity is it when the person produces the antibody themselves following immunization or infection?

Answer 1

Active immunity

Question 2

Between active and passive, which immunity ‘remembers’ and which one does not?

Answer 2

Active does, acquired does not

Question 3

What type of immunity is it when the an antibody is transferred to an individual? (Can be via IVIg, or placental transfer)

Answer 3

Passive immunity (“Pass it on”)

Question 4

What type of immunity is associated with rubella immunization?

Answer 4

Active immunity

Question 5

What type of immunity is associated with neonatal (<4 momths), syphillitic IgG antibody titers?

Answer 5

Passive (These antibodies are only temporary)

Question 6

Which immunity is this?
Non-specific, no memory, consists of exogenous (skin), endogenous (stomach acid), phagocytosis (PMNs), NK cells

Answer 6

Natural (innate)

Question 7

Which immunity is this?
Specific, memorizes, consists of T-cells (cytokines) and B-cells (antibodies)

Answer 7

Adaptive (acquired)

Question 8

What are the two types of acquired (adaptive) immunity?

Answer 8

Cellular and humoral

Question 9

Cellular immunity consists of what type of cells?

Answer 9

T-cell and lymphokines

Question 10

What does the cell mediated immunity primarily defend against?

Answer 10

Viral/fungal infections (intracellular organisms)

Question 11

Hypersensitivity type IV (delayed) is an example of what type of immunity?

Answer 11

Cell-mediated

Question 12

Humoral response produces what cells?

Answer 12

B cell (plasma cells)/antibodies

Question 13

Humoral primarily defends against

Answer 13

extracellular organisms

Question 14

Hypersensivity I, II, and III are all examples of what type of immunity?

Answer 14

Humoral immunity

Question 15

Which class has the greatest concentration in serum?

Answer 15

IgG

Question 16

Which immunoglobulin can cross the placenta?

Answer 16

IgG

Question 16

Which immunoglobulin activates compliment?

Answer 16

IgG4 (except IgG4)

Question 16

Which Ig fixes complement best? Why?

Answer 16

IgM; multiple binding sites

Question 17

Which Ig serves as the primary defense against local infections at the mucousal surface?

Answer 17

IgA

Question 17

Which immunoglobulin is the largest? (pentamer)

Answer 17

IgM

Question 17

Which immunoglobulin is the predominant antibody in body secretions (Tears, saliva, nasal mucosa)?

Answer 17

IgA

Question 17

Which Ig is prominent in early immune response (indicates acute infection)?

Answer 17

IgM

Question 17

Which IgA is a monomer? Which IgA is a dimer?

Answer 17

Serum IgA (monomer)
Secretory IgA (dimer)

Question 18

Which Ig has an unknown function?

Answer 18

IgD

Question 19

Which Ig is present on B-cell surface?

Answer 19

IgD

Question 20

Which Ig is seen in people with allergies or type 1 hypersensitvity?

Answer 20

IgE

Question 21

Which Ig is involved in release of histamines from mast cells?

Answer 21

IgE

Question 22

What is the order of Ig's ranked from greatest plasma concentration to lowest plasma concentration?

Answer 22

GAMDE

Question 23

What is the historical method rosette test? What is the process?

Answer 23

Evaluates T and B cells; Incubate sheep red blood cells with known number of purified lymphocytes --> SRBCs bind to E-rosette receptoy (CD2) on T-cells --> Counted rosetted lymphocytes; Percentage of T-cells can be calculated

Question 24

How to estimate B cells after a historical method-rosette test?

Answer 24

100% - calculated percentage of T cells