BM1022 5

Question 1

Hypersensitivity

Answer 1

Hypersensitivity can be defined as an abnormal state of immune reaction that can have deleterious effects on the host.

There are normal and, in most cases, essential immune responses that are exaggerated to the point that damage occurs.

4 TYPES

Question 2

Type 1 - immediate hypersensitivity reactions

Answer 2

PAPER

Question 3

Type 2 - cytotoxic hypersensitivity

Answer 3

Paper

Question 4

Type 3 immune complex mediated disease

Answer 4

Paper

Question 5

Type 4- delayed type hypersensitivity

Answer 5

Paper

Question 6

Immune deficiencies

Answer 6

Immune deficiencies can be classified as primary, where there is a deficiency in the gene resulting in the lack of a function that is important, and secondary
Where there is an external influence affecting the immune response

Question 7

Primary immune deficiencies

Answer 7

These occur when there is a deficient gene responsible for the production of one or more proteins Essential for a normal immune response

The deficiency may affect only a small part of the immune system or result in a combined immunodeficiency with disastrous consequences, if it affects a fundamental part of the development of both T and B cells

Question 8

Secondary immune deficiencies

Answer 8

These can result from a variety of factors including malnutrition, renal failure, diabetes, burns, the effect of drugs including immunosuppressants as well as infectious diseases such as HIV

Question 9

Autoimmunity

Answer 9

Autoimmunity occurs when tolerance fails. Either antibodies or T cells recognise self antigens and a series of reactions occur that cause host cell and tissue damage.
All 4 types of hypersensitivity occur

Conditions include: lupus, type I diabetes and rheumatoid arthritis