Blood Vessels Flashcards
1
Q
Arteries & Arteriosclerosis
A
-
From inner to outer layers -
- Intima (endo cells)
- Basement membrane (internal elastic lamina)
- Media (smooth muscle)
- Adventitia (anchor vessel)
- Sclerosis = Hardening of artery/arterioles
- Thickening & LOSS of elasticity of BV wall
- AterioloSclerosis-Hyaline assoc w/Kidney
- 3 forms:
- **Monckeberg medial calcific **
- Athero
- Arteriolo (associated w/Hypertension & Diabetes)
2
Q
Arteriosclerosis-Monckeberg Medial Calcific
A
- Calcium deposits found in the tunica media of muscular arteries
- In pelvis, upper limbs, uterus in ages ABOVE 50
- Dytrophic calcification (no clinical significance)
- Non-occulsive = No affect on blood flow
- Diagnosed w/Xray or mammogram
-
Symptoms:
- Arterial stiffness
- High pulse pressure
- Damage to Heart/Kidney
3
Q
Atherosclerosis (ATH)
A
- Definition: migration of smooth muscle cells from media to intima of large to medium sized arteries
- Media of arterty is thinned out
- Intimal injury = Intimal thickening, fatty streak (macrophages), Ingested LDL (Foam cells),Migration = intimal thickening LEADS to degradation of collagen/elastin
-
Intimal atheromatous or *fibro-fatty plaque:*
- Fibrous cap (smooth muscle cells, foam cells, neovascularization-Sprouting of new BVs from exsisting ones)
- Necrotic center-cholesterol crystals & calcium
- Atheromatous turns into complex lesion AKA Rupture/Thrombus
4
Q
Risk Factors & ATH
A
Risk factors:
-
Potentially controllable-
- LDL cholesterol
- Diabetes
- Hypertension
- Smoking
- Hyperlipidemia (HIGH LDL, LOW HDL or defective LDL receptor)
- Chlamydia
-
Non-controllable-
- Increasing age
- Males & post menopausal (estrogen def)
- Family history
- Physical inactivity
5
Q
Stages of ATH
A
-
Normal to Fatty streak-
- Endothelial dysfunction
- Monocyte adehesion
- SMC migration to intima
- SMC proliferation
- ECM elaboration
- Lipid accumulation
-
Fibrofatty plaque to Adv vulnerable plaque-
- Cell death/degeneration
- Inflammation
- Growth & remodeling of plaque/ECM
- Organization of thrombus w/calcification
- Mural thrombis embolization wall weakened = aneurysm/rupture
- Plaque rupture, erosion, hemmorhage = Occulsion by thrombus
- Plaque growth = Critical stenosis
6
Q
Morphology of Atheroma
A
- Location:
- Most common abdominal aorta
- Thoracic aorta
- Circle of Willis
- Renal & mesenteric arteries
- Rupture, ulceration or erosion = Thrombus formation
- Hemorrhage (coronary arteries) = Thrombus formation
- Calcification = Dystrophic type ID with X-ray
-
Aneurysmal dilation = Atrophy of smooth muscle of media/LOSS of elastic tissue
- Pulsating mass in abdomen (below renal artery)
- Rupture & hemm shock = Sudden loss of BP, cool skin, Loss of consciousness
7
Q
Clinical Signs of ATH
A
-
Symptoms due to LOW tissue O2:
- Coronary artery-Pain w/exercise
- Brain-TIA & stroke
- GIT-Mesenteric artery ATH=Ischemia of intestine (postprandial pain-Pain after eating & weight loss)
-
Lower extremities-ATH of popliteal:
- Gangrene of legs
- Impotence
- Pain on walking
- Renal artery (bilateral):
- Elevated renin/aldosterone = Secondary hypertension
8
Q
Hypertension
A
- Sustained diastolic BP above 90mmHg or systolic pressure in excess of 140mmHg
-
Malignant hypertension = Diastolic greater than 120 / Systolic greater than 200
- ex. Pheochromocytoma
- Risk factor for:
- CAD (coronary artery disease)
- CVA or Stroke (cerebro-vascular accident)
-
Idopathic HT:
- 90-95% compatible w/long life
- Family history IMPORTANT
- Present for 10-20years
-
Secondary HT:
- 5-10%
- Related to renal issues (renal hypo-perfusion)
- Sudden presentation
9
Q
Primary (essential) Hypertension
A
- Aka-Benign HTN = Long standing
- Family history present
- No short term problems
- Compications from MI or CVD
- Salt-sensitive hypertension w/normal renin activity
-
Genetic factors-Single gene disorder
- Increase aldosterone secretion
- Defect in renal Na+ homeostasis
- Increases to-Cardiac output, peripheral resistance & ECF = Hypertension
10
Q
Secondary HTN
A
-
Renal:
- Chronic renal disease
- Renal artery stenosis
- Renin producing tumors (renal cell carcinoma)
-
Endocrine:
- Pheochromocytoma = Increase in catecholamines
- Conn’s syndrome = Adenoma in adrenal cortex (increase in aldosterone w/decrease in renin)
- Cushing syndrome (high lvls or cortisol)
- Cardiovascular: Coarction of aorta=Upper limb HTN & Poly arteritis Nodosa (vasculitis w/clinical sign “rosary beads”)
- Neurological: increased intracranial pressure
11
Q
Renal artery stenosis (Fibro-muscular)
A
- Can be unilateral greater chance in females
-
Histo: Deposition of trichrome positive collagen in artery wall w/Medial hyperplasia (Beads on a string)
- Found in lamina elastic interna
-
Hypoxia = High renin & aldosterone in serum of affected vessels
- Net effect = Small atrophic kidney
- Malignant Hypertension =Visual Kidney changes
12
Q
Malignant Hypertension
A
- Hyaline arteriolosclerosis:
- Arteriolar wall becomes hylinized = Narrow lumen
- Kidney = Fine granular change (benign nephrosclerosis)=Severe forms seen Diabetes
- Histo: Pink glossy in wall
- Hyperplastic = onion skinning leads to luminal obliteration (ischemia-wrinkling of glom capillary vessels)
- Kidney = multiple hemorrhages (flea-bitten) assoc w/glomerular damage
- Can be assoc w/Fibrinoid necrosis - Deposits of eosinophilic material in intima
13
Q
Clinical signs of Malignant HTN
A
- Palpitation
- Irregularly irregular HB
- Brought on by peripheral edema=CHF
- Blurring vision
- Headache
- Emergency HTN:
- Renal failure (hematuria)
- Retinal hemorrhages
-
Papilledema (increased intracranial presure)
- Swelling of optic disk
- Diseases assoc w/HTN:
- Left vent hypertrophy
- Benign nephrosclerosis
- Berry’s aneurysm
14
Q
Aneurysms
A
- Localized abnormal dialtion of a BV (vein or artery) or dialtion of heart
-
Most common causes for aortic:
- Atherosclerosis
- Hypertension
-
Cystic medial degeneration (necrosis):
- Loss of elastic muscle fibers in media & replaced w/basophilic ground substance
- Marfan syndrome (defective fibrillin needed to make elastic fibers)
- Cong. defects = Berry aneurysms (subarachnoid space hem)
- Syphilis (spirochete bacter) affects thoracic aorta
- Mycotic = due to infection of major artery
15
Q
Abdominal Aortic Aneurysms
A
- Most common
-
Cause:
- Atherosclerosis
-
Location:
- Below renal arteries & above bifurcation of aorta
-
Complications:
- Rupture into peritoneal cavity or retro = SHOCK
- Develop mural thrombus = Lower body embolism (impotence & gangrene)
- BP is crucial in severity of aneurysm