Blood Vessels Flashcards

1
Q

Arteries & Arteriosclerosis

A
  • From inner to outer layers -
    • Intima (endo cells)
    • Basement membrane (internal elastic lamina)
    • Media (smooth muscle)
    • Adventitia (anchor vessel)
  • Sclerosis = Hardening of artery/arterioles
  • Thickening & LOSS of elasticity of BV wall
  • AterioloSclerosis-Hyaline assoc w/Kidney
  • 3 forms:
  1. **Monckeberg medial calcific **
  2. Athero
  3. Arteriolo (associated w/Hypertension & Diabetes)
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2
Q

Arteriosclerosis-Monckeberg Medial Calcific

A
  • Calcium deposits found in the tunica media of muscular arteries
  • In pelvis, upper limbs, uterus in ages ABOVE 50
  • Dytrophic calcification (no clinical significance)
  • Non-occulsive = No affect on blood flow
  • Diagnosed w/Xray or mammogram
  • Symptoms:
    • Arterial stiffness
    • High pulse pressure
    • Damage to Heart/Kidney
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3
Q

Atherosclerosis (ATH)

A
  • Definition: migration of smooth muscle cells from media to intima of large to medium sized arteries
  • Media of arterty is thinned out
  • Intimal injury = Intimal thickening, fatty streak (macrophages), Ingested LDL (Foam cells),Migration = intimal thickening LEADS to degradation of collagen/elastin
  • Intimal atheromatous or *fibro-fatty plaque:*
    • Fibrous cap (smooth muscle cells, foam cells, neovascularization-Sprouting of new BVs from exsisting ones)
    • Necrotic center-cholesterol crystals & calcium
  • Atheromatous turns into complex lesion AKA Rupture/Thrombus
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4
Q

Risk Factors & ATH

A

Risk factors:

  • Potentially controllable-
    • LDL cholesterol
    • Diabetes
    • Hypertension
    • Smoking
    • Hyperlipidemia (HIGH LDL, LOW HDL or defective LDL receptor)
    • Chlamydia
  • Non-controllable-
    • Increasing age
    • Males & post menopausal (estrogen def)
    • Family history
    • Physical inactivity
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5
Q

Stages of ATH

A
  • Normal to Fatty streak-
    • Endothelial dysfunction
    • Monocyte adehesion
    • SMC migration to intima
    • SMC proliferation
    • ECM elaboration
    • Lipid accumulation
  • Fibrofatty plaque to Adv vulnerable plaque-
    • Cell death/degeneration
    • Inflammation
    • Growth & remodeling of plaque/ECM
    • Organization of thrombus w/calcification
  • Mural thrombis embolization wall weakened = aneurysm/rupture
  • Plaque rupture, erosion, hemmorhage = Occulsion by thrombus
  • Plaque growth = Critical stenosis
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6
Q

Morphology of Atheroma

A
  • Location:
  • Most common abdominal aorta
  • Thoracic aorta
  • Circle of Willis
  • Renal & mesenteric arteries
  • Rupture, ulceration or erosion = Thrombus formation
  • Hemorrhage (coronary arteries) = Thrombus formation
  • Calcification = Dystrophic type ID with X-ray
  • Aneurysmal dilation = Atrophy of smooth muscle of media/LOSS of elastic tissue
    • Pulsating mass in abdomen (below renal artery)
    • Rupture & hemm shock = Sudden loss of BP, cool skin, Loss of consciousness
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7
Q

Clinical Signs of ATH

A
  • Symptoms due to LOW tissue O2:
    • Coronary artery-Pain w/exercise
    • Brain-TIA & stroke
    • GIT-Mesenteric artery ATH=Ischemia of intestine (postprandial pain-Pain after eating & weight loss)
  • Lower extremities-ATH of popliteal:
    • Gangrene of legs
    • Impotence
    • Pain on walking
  • Renal artery (bilateral):
  • Elevated renin/aldosterone = Secondary hypertension
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8
Q

Hypertension

A
  • Sustained diastolic BP above 90mmHg or systolic pressure in excess of 140mmHg
  • Malignant hypertension = Diastolic greater than 120 / Systolic greater than 200
    • ex. Pheochromocytoma
  • Risk factor for:
  • CAD (coronary artery disease)
  • CVA or Stroke (cerebro-vascular accident)
  • Idopathic HT:
    • 90-95% compatible w/long life
    • Family history IMPORTANT
    • Present for 10-20years
  • Secondary HT:
    • 5-10%
    • Related to renal issues (renal hypo-perfusion)
    • Sudden presentation
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9
Q

Primary (essential) Hypertension

A
  • Aka-Benign HTN = Long standing
  • Family history present
  • No short term problems
  • Compications from MI or CVD
  • Salt-sensitive hypertension w/normal renin activity
  • Genetic factors-Single gene disorder
    • Increase aldosterone secretion
    • Defect in renal Na+ homeostasis
  • Increases to-Cardiac output, peripheral resistance & ECF = Hypertension
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10
Q

Secondary HTN

A
  • Renal:
    • Chronic renal disease
    • Renal artery stenosis
    • Renin producing tumors (renal cell carcinoma)
  • Endocrine:
    • Pheochromocytoma = Increase in catecholamines
    • Conn’s syndrome = Adenoma in adrenal cortex (increase in aldosterone w/decrease in renin)
    • Cushing syndrome (high lvls or cortisol)
  • Cardiovascular: Coarction of aorta=Upper limb HTN & Poly arteritis Nodosa (vasculitis w/clinical sign “rosary beads”)
  • Neurological: increased intracranial pressure
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11
Q

Renal artery stenosis (Fibro-muscular)

A
  • Can be unilateral greater chance in females
  • Histo: Deposition of trichrome positive collagen in artery wall w/Medial hyperplasia (Beads on a string)
    • Found in lamina elastic interna
  • Hypoxia = High renin & aldosterone in serum of affected vessels
    • Net effect = Small atrophic kidney
  • Malignant Hypertension =Visual Kidney changes
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12
Q

Malignant Hypertension

A
  • Hyaline arteriolosclerosis:
  • Arteriolar wall becomes hylinized = Narrow lumen
  • Kidney = Fine granular change (benign nephrosclerosis)=Severe forms seen Diabetes
  • Histo: Pink glossy in wall
  • Hyperplastic = onion skinning leads to luminal obliteration (ischemia-wrinkling of glom capillary vessels)
  • Kidney = multiple hemorrhages (flea-bitten) assoc w/glomerular damage
    • Can be assoc w/Fibrinoid necrosis - Deposits of eosinophilic material in intima
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13
Q

Clinical signs of Malignant HTN

A
  • Palpitation
    • Irregularly irregular HB
    • Brought on by peripheral edema=CHF
  • Blurring vision
  • Headache
  • Emergency HTN:
  • Renal failure (hematuria)
  • Retinal hemorrhages
  • Papilledema (increased intracranial presure)
    • Swelling of optic disk
  • Diseases assoc w/HTN:
  • Left vent hypertrophy
  • Benign nephrosclerosis
  • Berry’s aneurysm
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14
Q

Aneurysms

A
  • Localized abnormal dialtion of a BV (vein or artery) or dialtion of heart
  • Most common causes for aortic:
    • Atherosclerosis
    • Hypertension
  • Cystic medial degeneration (necrosis):
    • Loss of elastic muscle fibers in media & replaced w/basophilic ground substance
    • Marfan syndrome (defective fibrillin needed to make elastic fibers)
  • Cong. defects = Berry aneurysms (subarachnoid space hem)
  • Syphilis (spirochete bacter) affects thoracic aorta
  • Mycotic = due to infection of major artery
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15
Q

Abdominal Aortic Aneurysms

A
  • Most common
  • Cause:
    • Atherosclerosis
  • Location:
    • Below renal arteries & above bifurcation of aorta
  • Complications:
    • Rupture into peritoneal cavity or retro = SHOCK
    • Develop mural thrombus = Lower body embolism (impotence & gangrene)
  • BP is crucial in severity of aneurysm
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16
Q

Syphilitic (Leutic) Aneurysms

A
  • Location = Thoracic aorta
  • Tertiary syphilis:
    • Inflammation of adventia
    • Leads to inflammation of Vasa vasorum <strong>(Blood supply of aorta)</strong>=Obliterative endarteritis
    • Loss of elastic fibers = Ischemia
    • End result dilatation of thoracic aorta
  • Appearance: “Tree bark” - wrinkled
  • Cardiac disease: Aortic valve dialation or regurg
  • Massive left vent hypertrophy & dialation = Cor bovinum
  • Diagnose w/Ab for Treponema Pallidum
17
Q

Aortic Dissection General

A
  • Tear in the intima (inner layer) = Intramural hematoma
  • Presence of blood between & along the laminar planes of media (outer/middle)
  • Causes DILATATION & Dissecting aneurysms
  • Histo: Medial degeneration marked by elastin fragmentation (Marfan)=Black lines are scattered not consistant
  • Proximal dissection: ascending aorta complete or region of aortic valve <strong>(arch)</strong>
  • Predisposing factors:
  • Hypertension, 40-60, any part of aorta
  • Marfan:
  • Myxoid change & fragmentation of elastic lamina (cystic medial necrosis)
  • Above or AT aortic root
18
Q

Clinical Presentation of Aortic Dissection

A
  • Propagation of SUBintimal hematoma:
    • Makes true/false lumen w/in aorta = Double barreled aorta
    • False lumen grows = Decrease amount of blood flow in true
  • Dissection w/in pericardial space = Cardiac tamponade
  • Dissection @ root = tamponade, wide mediastinum (heart shadow), diminished heart sound, SUDDEN collaspe/shock
  • ECG: ST segment elevations (vent depolar) can be mistaken w/MI
    • ST depression also happens more severe
  • Tearing chest pain-Radiate to back
  • Shifting pain w/time
19
Q

Giant cell (temporal) Arteritis General

A
  • Acute or chornic granulomatous inflammation w/lymphocytic infiltrate
  • Histo:
  • Degenerated internal elastic membrane in acute arteritis
  • Intimal thickening in chronic or healed arteritis
  • Nodular thickening of affected artery
  • Involves:
    • Temporal artery-Headache
    • Opthalmic-blindness, diplopia
    • External carotid artery-Trans Ischemic attack less than 24 hours
20
Q

Clinical features of Giant cell (temporal)

A
  • After age 50
  • Polymyalgia rheumatica (joint/muscle pain) neck & shoulder stiffness/pain
  • Jaw pain
  • Abrupt headaches
  • Weight loss/Anorexia
  • Loss of vision
  • Lab value: High ESR (sedimenation rate) sticky due to fibronogen inflammation=over 100mmHr
  • Corticosteroid therapy sucessful
21
Q

Takayasu Arteritis (Pulseless disease)

A
  • Granulomatous vasculitis autoimmune marker ANCA (antineutrophil cytoplasmic Ab)
  • Destruction of media by mononuclear inflammation
  • AKA aortic arch syndrome
  • Females younger than 40
  • Vessels involved:
    • Aortic Arch
    • Renal=secondary hypertension
    • Pulmonary
  • Imaging: Narrowing of brachiocephalic, carotid & subclavian arteries
  • Morphology: Stenosis & or aneurysm
  • Clinical:
  • Low BP w/weak pulse in upper (carotid, radial, ulnar) than in lower
  • Ocular disturbances-Unilateral blindness
22
Q

ANCA vasculitis

A
  • Anti-neutrophil cytoplasmic Ab
  • Wegner granilomatosis = C-anca
  • Churg-Strauss = P-anca
    • Asthma & eosinophila
    • Fibrinoid necrosis
  • Microscopic polyangitis = P-anca
    • NO asthma
    • Neutorphil infiltration in BV
23
Q

Polyarteritis Nodosa (PAN)

A
  • Systemic vasculitis (medium vessel)
  • Hep B Surface Ag (HBsAg)+++
  • ANCA (-)
  • Perfusion impairment=infarcts-necrosis
  • Involves:
    • Kidney
    • Skin
    • Other organs
    • NO LUNG
  • Morphology:
    • Fibrinoid necrosis (bright pink fibrin Ca+2 deposit)
    • Thrombosis
  • Clinical PAN:
  • Effects all age groups
  • Malaise, fever, weight loss
  • HT w/ab pain w/Melena (tar feces)
  • *palpable skin purpura *
24
Q

Churg-Strauss Syndrome

A
  • Autoimmune of medium & small vessels w/History of airway allergy sensitivity
  • Variant of PAN
  • Allergic granuloma invloving PULMONARY vasculature
  • Eosinophila = Damage to vessels & necrosis
  • Symptoms:
    • Asthma
    • Allergic Rhinitis
  • Positive for P-ANCA target for myloperoxidase
25
Q

Kawasaki Disease

A
  • Mucocutaneous lymph node syndrome
  • Effects young children
  • Associated w/Auto-immune or pathogen
  • Clinical:(Triad of symptoms)
  • Conjunctivitis
  • Maculopapular skin rash
  • Lymphadenopathy
  • Redness on soles/palms
  • Location:
  • Right & Left Coronary artery leads to MI due to aneurysm
26
Q

Leukocytoclastic Vasculitis

A
  • Microscopic polyangitis-Affects Arerioles, capillaries, venules
  • Etiology-reaction to an Ag like:
    • Drugs (penicillin)
    • Microorganisms (strep)
    • Malignancy
  • Characteristic:
    • Deposition of antigen-Ab complex in vessel wall
    • P-ANCA (+) detected by Myeloperoxidase
    • Palpable skin purpura (more common than PAN)
    • Blood stained sputum (hemoptysis)
    • Arthalgia <strong>(joint pain)</strong>
  • Morphology: **Neutrophilic vasculitis **
    • Non-granulomatous-neutrophil/lymphocytes
27
Q

Henoch-Schonlein Purpura

A
  • Type of leukocytoclastic vasculitis ID by IgA mediated skin purpura
  • IgA deposition in kidney = Hematuria
    • Depostition in Glom
  • Peri-vascular IgA deposit in skin = DERMATITIS HERPETIFORMIS
  • P-ANCA (-)
  • Abdominal manifestations:
    • Pain
    • Vomiting
    • Intestinal bleeding
    • nonmigratory arthralgia
28
Q

Systemic Lupus Erythematosus

A
  • Fibrinoid necrosis present
  • Ab in SLE:
    • Anticardiolipin Ab=Deep venous thrombosis (antiphospholipid syndrome)
    • ds-DNA & Anti-smith
  • Pts w/o C2-C4 are more susceptable to SLE
  • Hep-B pts more susceptible to Fibrosis
29
Q

Wegner Granulomatosis

A
  • Necrotizing vasculitis - affecting capillaries, venules, arterioles, & arteries
  • Morphology-Giant cells in lung/kidney Blood vessels
  • Nodular infiltrative lesions in lung
  • Affects BOTH upper/lower
  • Causes palatal destruction
  • Death w/in 1 year if untreated
  • c-ANCA (+) in seurm 95% and can monitor disease progression
  • Nasopharynx-Mucosal ulceration, sinusitis, rupture of nasal septum=<u>Bleeding</u>
  • Lung- pneumonitis
  • Kidney:
  • Crescentic glomerulonephritis
  • acute renal failure
  • Secondary Hypertension
30
Q

Raynaud Phenomenon

A
  • Primary (disease) = Vasoconstriction due to cold, stress <strong>(neurological)</strong>
  • Secondary (phenomen) = Pathological obstruction of artery
    • Buerger
    • Scleroderma (fibrosis)
    • SLE
  • Burger = Claudication (trouble walking) of feet
  • Affects tibial & raidal artery
  • Color change = White-Blue-Red
  • Kidney **meningioma present **
31
Q

DVT

A
  • Cause = Hypercoagulable states
    • Adenocarcinoma (colon, lung, urogenital)-Can start off as trousseau syndrome
    • Pregers
    • Immobilization
    • Bone fracture
  • Vessels: Iliac, femoral, Popliteal MOST common
  • Saddle thrombus ->Acute cor pulmonale (RHF)->pulmonary infarction = Acute dyspnea (Quick death)
32
Q

Benign Vascular Tumors (Spider Telangictasia)

A
  • Arterial Spider
  • Radial & often pulsatile
  • Array of dilated subcutaneous arteries or arterioles w/central core
  • Etiology:
    • Hyperestrinism seen in liver failure due to liver not breaking down estrogen
    • Gyenecomastia SE (males)
    • Cirrhosis w/portal HTN
33
Q

Hereditary Hemorrhagic telangiectasis

A
  • Osler-weber-rendu disease (angiodysplasia)
  • Autosomal dominant
  • _Morphology: _
  • Vascular deformation = meshwork dilated capillaries, veins, arteries
  • Arterio-venous malformation = Hamartoma <strong>(thick wall artery & thin wall veins together)</strong>
  • Location:
  • Present @ birth
  • Distrubuted widely over skin & mucous membranes
  • Clinical presentation:
  • Spontaneous nosebleeds
  • Bleeding into gut/rectum
  • Hematuria
34
Q

Hemangiomas

A
  • Capillary hema:
    • Benign BV
    • Found on skin rarely visceral organ (interior organ)
    • Red skin nodule (strawberry)
    • Regresses spontaneously
  • Cavernous hema:
    • Large cavernous vascular spaces & dystrophic calcification
    • Found on visceral organs
  • Associated w/Von Hippel-Lindau disease
  • Hemangioblastoma (tumors of CNS) in:
    • cerebellum
    • eye & bilateral renal cell
    • Cysts in liver/kidney
    • Pheochromytoma
35
Q

Cavernous Lymphangioma

A
  • “Cystic Lymphangioma”
  • Common in children in Neck or Axilla
  • Defined by size *15 CM in diameter *
  • Composed of massively dilated-cystic lymphatic vessels
  • Associated w/Turner’s syndrome (45X)
  • Causes diff in delivery
36
Q

Bacillary Angiomatosis

A
  • Moist, erosive CUTANEOUS lesion
  • _Histo: _
  • Acute neutrophilic inflammation
  • Vascular (capillary) prolif
  • Silver (Warthin-Starry) stain=Tangled bacilli
  • Appearance-Black
  • Assoc w/Bartonella Henselae (cat-stratch)
37
Q

Kaposi Sarcoma

A
  • Gross: Red-purple macules & plaques on skin
  • Histo: nodular form-sheets of plump proliferating Spindle cells (CD31)
    • extravasation of RBCs
  • Markers: Vimentin (anchoring)
  • Dermal angiosarcoma (malignant neoplasm of endothelial cells)
  • Cause = HSV-8 (herpes) affects HIV or immuno-comprimised pts
  • Mech: KSHV incorporates in host genome
    • Disrupt control of cellular proliferation-inactivating Rb gene
    • Prevents apoptosis of endo cells w/production of tp53 inhibitors (tumor inhibitor)