Blood Transfusion

Question 1

Recall the major blood groups

Answer 1

A
B
AB
O

Question 2

What is a blood cell antigen made up of?

Answer 2

Sugar and stem (glycoprotein + fructose)

Question 3

Recall the glycoprotein in the A and B antigen genes

Answer 3

A - N-acetyl glycosamine

B - galactose

Question 4

What % of the population are RhD positive?

Answer 4

85%

Question 5

What genotypes are RhD positive?

Answer 5

Dd and DD

Question 6

Recall the pathophysiology of haemolytic disease of the newborn

Answer 6

RhD negative mother has RhD positive baby = allergic reaction

Question 7

Which immunoglobin has Ab against every non-self erythrocyte?

Answer 7

IgM

Question 8

How can blood group be tested for?

Answer 8

Agglutenation (IgM will agglutenate all non-self)

Question 9

Recall the shelf lives and storage requirements of Red cells, FFP, platelets and cryoprecipitate

Answer 9

Red cells = 5 weeks at 4 degrees C
FFP = 2 years at -30 degrees C
Platelets = 5 days at 22 degrees C
Cryoprecipitate = 2 years at -30 degrees C