Blood Pressure And Hypertension In Small Animals Flashcards
2 major contributors to arterial blood pressure
Peripheral resistance and cardiac output
Baroreceptors detect
Minute to minute variations
Baroreceptors are found
Carotid sinus and aortic arch
RAAS is for detecting
Long term regulation
RAAS compensatory to
Reduction in blood pressure
With chronic activation of RAAS you see
Endothelial dysfunction, tissue fibrosis, cellular remodeling, proteinuria
With hypovolemia the kidney makes
Renin
Renin goes where to do what
Liver to convert angiotensinogen to angiotensin 1
Angiotensin 2 happens where
Lungs
What converts angiotensin 1 to 2
ACE convertin enzymes
Angiotensin 2 is a potent
Vasoconstriction
Angiotensin also goes to
Adrenal gland
Angiotensin 2 releases
Aldosterone
Constriction of efferent arterioles increases
Golmerular capillaty pressure
Angiotensin constricts
Efferent arterioles
RAAS blockade
Ace inhibitors to block AG 1 - 2 and ARB blocking receptors
Aldosterone is a
Mineralcorticoid
Aldosterone comes from
Zona glomerulosa
What is the 2 stimuli release aldosterone
Angiotensin 2 and hyperkalemia
How does aldosterone effects kidney
Principle cells, potassium excretion, and sodium retention
What is the mineralocorticoid with hypoadrencorticism
Deficiency
What is K and Na with mineralcorticoid deficieny
Increase K and decrease Na
With hyper aldosterone what is the Na and K
N to increase Na and decreased K
Cuff width for BP
30 - 40 % of the circumference of the cuff site