Blood Pressure And Hypertension In Small Animals Flashcards

1
Q

2 major contributors to arterial blood pressure

A

Peripheral resistance and cardiac output

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2
Q

Baroreceptors detect

A

Minute to minute variations

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3
Q

Baroreceptors are found

A

Carotid sinus and aortic arch

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4
Q

RAAS is for detecting

A

Long term regulation

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5
Q

RAAS compensatory to

A

Reduction in blood pressure

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6
Q

With chronic activation of RAAS you see

A

Endothelial dysfunction, tissue fibrosis, cellular remodeling, proteinuria

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7
Q

With hypovolemia the kidney makes

A

Renin

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8
Q

Renin goes where to do what

A

Liver to convert angiotensinogen to angiotensin 1

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9
Q

Angiotensin 2 happens where

A

Lungs

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10
Q

What converts angiotensin 1 to 2

A

ACE convertin enzymes

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11
Q

Angiotensin 2 is a potent

A

Vasoconstriction

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12
Q

Angiotensin also goes to

A

Adrenal gland

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13
Q

Angiotensin 2 releases

A

Aldosterone

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14
Q

Constriction of efferent arterioles increases

A

Golmerular capillaty pressure

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15
Q

Angiotensin constricts

A

Efferent arterioles

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16
Q

RAAS blockade

A

Ace inhibitors to block AG 1 - 2 and ARB blocking receptors

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17
Q

Aldosterone is a

A

Mineralcorticoid

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18
Q

Aldosterone comes from

A

Zona glomerulosa

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19
Q

What is the 2 stimuli release aldosterone

A

Angiotensin 2 and hyperkalemia

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20
Q

How does aldosterone effects kidney

A

Principle cells, potassium excretion, and sodium retention

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21
Q

What is the mineralocorticoid with hypoadrencorticism

A

Deficiency

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22
Q

What is K and Na with mineralcorticoid deficieny

A

Increase K and decrease Na

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23
Q

With hyper aldosterone what is the Na and K

A

N to increase Na and decreased K

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24
Q

Cuff width for BP

A

30 - 40 % of the circumference of the cuff site

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25
IF cuff is too narrow
Overestimates BP
26
If cuff is too wide
Underestimates BP
27
2 sites for cuff
Limb and tail base
28
Take how many BP measurements
5 - 7
29
Written record for BP
Cuff size, site, animal position, values, final , interpretation, name person taking measurements
30
Gold standard for measuring BP
Direct - arterial catheterizaiton
31
Indirect measurement of BP
Doppler ultrasonic flow detector and oscillometry
32
A Doppler measures dog ____ arterial BP
Systolic
33
A Doppler better predicts ___ arterial BP
Mean
34
What are some cons of Doppler
Peripheral vasoconstriction can make it hard to hear
35
Oscillometric ____________ is most accurate reading
Mean arterial BP
36
Cons of oscillometric
Less accurate and affected by patient
37
White coat hypertension
Anxiety and stress - catecholamines
38
Secondary hypertension
Persistent, pathological increase in BP
39
Secondary hypertension is concurrent with
Disease and drugs
40
If disease known to cause secondary hypertension then what is indicated
Serial BP monitoring
41
What is the most common cause of pathological hypertension in dogs/cats
Secondary hypertension
42
What disease can cause secondary hypertension
Daiabetes mellitus, hyperthyroidism, hyperadrenocorticism, hyperaldosteronism, pheochromocytoma
43
Idiopathic or primary hypertension
Persistent pathological hypertension in the absence of an underlying identifiable cause
44
Target organ damage of high blood pressure
Eyes, kidney, Heart, brain
45
Annual screening for all dogs and cat BP if how old
Greater than 9
46
Treatment of hypertension
Gradual persistent reduction over weeks
47
Target BP
Less than 160 mmHg
48
Why can hypertension persist after treating underlying disease
Vascular remodeling
49
Which hypertension is hard to prove in dogs and cats
Idiopathic hypertension - renal disease
50
Hypertensive
160 - 179
51
If its greater than 180 recheck
Wishing 1 - 2 weeks
52
If 140 - 179 recheck
4 - 8 weeks
53
If 140 - 159 monitor for
6 months
54
RAAS inhibitors
Ace inhibitors and angiotensin receptor blockers
55
Ace inhibitors
Enalapril and benzaepril
56
Calcium channel blockers cause
Arterial vasodilation - reduce vascular resistance
57
What is the frontline in cats
Calcium channel blockers
58
Calcium Channel Blockers
Amlodipine
59
RAAS inhibitors are frontline in dogs for
Mild to moderate hypertension in dogs
60
Side effects of calcium channel blockers
Hypotension, gingival hyperplasia and peripheral edema
61
Angiotensin receptor blockers
Tel is Arabian
62
RAAS inhibitors are weak only reduce
10 - 15
63
RAAS inhibitors side effects
GI side effects, electrolytes, worsening azotemia
64
RAAS inhibitors are not recommended for
Mono therapy for severe hypertension in dogs, frontline to for cat, dehydration, or azotemix