Blood Pressure Agents Flashcards
What are some risks related to hypertension?
Coronary Artery Disease
* hypertrophy/thickening of the heart muscle
* Increased pressure generated by the muscle contraction
* Increased workload on the heart
If HTN remains untreated:
* CAD and Cardiac Death
* Stroke
* Renal Failure
* Loss of vision
Normal Blood Pressure
<120mmHg AND <80mmHg
Elevated Blood Pressure Reading
120-129 mmHg AND <80mmHg
Hypertension Stage 1 Reading
130-139mmHg OR 80-89mmHg
Hypertension Stage 2 Reading
greater than/equal to 140mmHg OR
greater than/equal to 90mmHg
Modifiable Risk Factors for Hypertension
- Stress
- Cigarette Smoking
- Alcohol Use
- Obesity
- Decreased physical activity
- High Salt Diet
Non-modifiable Risk Factors for Hypertension
- Chronic Kidney Disease
- Increased Age
- Diabetes*
- Sleep Apnea*
- Genetic predisposition
*possibly modifiable
Lifespan considerations for Blood Pressure Agents
In Children
- More likely to be secondary HTN
- Use drug therapy with caution
- Lifestyle changes first: weight loss, increased activity
- Monitor BP closely
- With diuretics: monitor electrolytes and glucose closely
Lifespan considerations for Blood Pressure Agents
In Adults
- Lifestyle modifications first: weight loss, alcohol use, smoking, stress, activity
- Safety precautions: watch for dehydration from meds; chronic dehydration can also cause HTN
- Caution with pregnancy: Labetalol is first choice in pregnancy if needed. ACEI/ARB/Renin inhibitors are contraindicated in pregnancy.
- Drugs can enter breastmilk; choose alternative method of feeding
- Adverse effects should be reported immediately
Lifespan considerations for Blood Pressure Agents
In Older Adults
- More susceptible to toxic effects: Reduced doses; close monitoring
- Safety precautions: do not crush, cut, or chew ER or SR medications (will cause toxic dose)
- Fall risk r/t hypotension/orthostatic hypotension
- Monitor closely for dehydration
- In institutional settings, BP should be taken immediately before administering medication
Stepped Care Management of Hypertension
no need to memorize… just know the general idea
Step 1: Lifestyle modifications
Step 2: Drug therapy added
Step 3: Change in drug class or combination therapy
Step 4: Second or third agent or diuretic added if not already being used
Antihypertensive Agents
all of the drug classes
Drugs affecting the RAS
* ACE (Angiotensin Converting Enzyme) inhibitors
* Angiotensin II Receptor Blockers (ARBs)
* Renin Inhibitors
Calcium Channel Blockers
Vasodilators
Diuretics
Sympathetic Nervous System Blockers
* Beta Blockers: selective/non-selective
* Alpha Adrenergic Blockers: nonselective/Alpha 1 blockers
* Alpha AND Beta Blockers (aka Nonselective Adrenergic Blocking Agents)
* Alpha 2 Agonist
ACE Inhibitors
Mechanism of Action
Drugs affecting the RAS
- Blocks ACE from converting angiotensin I to angiotensin II in the RAAS
- This in turn blocks adosterone, leading to vasodilation, sodium and water excretion, and small increase in potassium
⬇️ decreased peripheral resistance (vasodilation)
⬇️ fluid volume (sodium/water loss)
⬇️ cardiac workload
ACE Inhibitor
Indications
Drugs affecting the RAS
- HTN
- Congestive Heart Failure
- Left Ventricular dysfunction
- Diabetic nephropathy prevention
ACE Inhibitor
Drug Names
Drugs affecting the RAS
“-pril”
Benazepril
Captopril
Enalapril
Lisinopril
Ramipril
ACE Inhibitor
Contraindications
Drugs affecting the RAS
Absolute:
* Allergy
* Pregnancy (Black Box warning)
Relative:
* Impaired renal function (makes it worse)
Caution:
* Acute/unstable CHF
ACE Inhibitor
Drug Interactions
Drugs affecting the RAS
- Allopurinol (increases the risk of blood dyscrasias)
- Other RAAS drugs
- NSAIDs (decrease the effect of ACEIs)
ACE Inhibitor
Adverse Effects
Drugs affecting the RAS
Related to vasodilation & alterations in blood flow:
* Hypotension
* Renal insufficiency
* Dizziness
* Fatigue
Other:
* Pancytopenia (depressed bone marrow)
* GI irritation
* Rash
* Hyperkalemia
* Dry, constant cough
* Reflex tachycardia
ACE Inhibitor
Specific assessments
Drugs affecting the RAS
Labs:
CBC: before and during treatment because of bone marrow depression
ACE Inhibitor
Specific Implementation
Drugs affecting the RAS
- Patient teaching regarding cough
Angiotensin II Receptor Blockers: ARBs
Mechanism of Action
Drugs affecting the RAS
- Angiotensin II Receptor Antagonist
-
Blocks angiotensin II from binding with the receptors on the vascular smooth muscle AND in the adrenal cortex
Prevents vasoconstriction
Prevents release of aldosterone
Angiotensin II Receptor Blockers: ARBs
Indications
Drugs affecting the RAS
- HTN
- CHF
- Diabetic nephropathy prevention
Angiotensin II Receptor Blockers: ARBs
Drug Names
Drugs affecting the RAS
“-sartan”
Candesartan
Irbesartan
Losartan
Olmesartan
Telmisartan
Valsartan
Angiotensin II Receptor Blockers: ARBs
Contraindications
Drugs affecting the RAS
Absolute:
* Allergy
* Pregnancy (Black Box warning)
Cautions:
* Hepatic dysfunction
* Renal dysfunction
* Hypovolemia
Angiotensin II Receptor Blockers: ARBs
Adverse Effects
Drugs affecting the RAS
- 🧠 CNS: Headache, dizziness, syncope, weakness
- 💓 CV: hypotension
- 💩 GI: N&V, abdominal pain, diarrhea
- Skin: Rash
- Hyperkalemia
- Renal damage
Angiotensin II Receptor Blockers: ARBs
Drug Interactions
Drugs affecting the RAS
- NSAIDs (dec. effect of ARBs)
- Other RAAS drugs
Angiotensin II Receptor Blockers: ARBs
Specific Assessment
Drugs affecting the RAS
History:
* Liver impairment
Labs:
* Liver function tests
Renin Inhibitor: Aliskiren
Mechanism of Action
Drugs affecting the RAS
- Inhibits renin release from kidney
- Which leads to inhibition of the RAAS
⬇️ decreased aldosterone
⬇️ decreased sodium reabsorption
⬇️ decreased Blood pressure
Renin Inhibitor: Aliskiren
Indication
Drugs affecting the RAS
Hypertension
Renin Inhibitor
Drug Name
Drugs affecting the RAS
Aliskiren
Renin Inhibitor: Aliskiren
Contraindications
Drugs affecting the RAS
Absolute:
* Allergy
* Pregnancy (Black Box Warning)
Renin Inhibitor: Aliskiren
Adverse Effects
Drugs affecting the RAS
- Hyperkalemia
- 💩 Diarrhea
Renin Inhibitor: Aliskiren
Drug Interactions
Drugs affecting the RAS
- Other drugs that affect the RAAS (increase in adverse effects)
Drugs affecting the RAAS
Assessment
History:
* Allergy
* Pregnancy
* Impaired kidney function, salt/volume depletion, heart failure
Physical:
* Baseline: cardiac, respiratory, abdominal, skin
* Vitals and weight (fluid volume)
Labs:
* Renal function tests
* Electrolytes
* Pregnancy test
Drugs affecting the RAAS
Nursing Diagnoses/Conclusions
- Altered tissue perfusion (r/t changes in cardiac output)
- Altered skin integrity (r/t dermatologic effects)
- Impaired comfort (r/t adverse effects)
- Electrolyte imbalance risk (r/t action of drug)
- Knowledge deficit
Drugs affecting the RAAS
Implementation/Patient Teaching
- Encourage lifestyle changes
- Use of barrier contraceptives
- Comfort and safety measures
- Monitor pt. carefully in any situation that might result in fluid loss (vomiting, diarrhea, dehydration)
- Teach patients to watch for warning signs
Calcium Channel Blockers
Mechanism of Action
- Inhibits the movement of calcium ions across the cell membranes in cardiac and arterial muscle
- Leads to a depressed impulse and slower conduction, decreased myocardial contractility, and relaxed dilated arteries
Calcium Channel Blockers
Indications
- Hypertension
- Angina
- Arrhythmias
Calcium Channel Blockers
Drug Names
“-dipine”
Amlodipine
Felodipine
Nifedipine
Diltiazem
Verapamil