Blood Groups- Genetics

Question 1

A family study consists of 4 daughters, 4 sons, and 12 grandchildren. One son and one daughter have an inherited genetic disorder that is not present in any of the grandchildren. This is an example
of:
a. Sex-linked dominant inheritance
b. Autosomal recessive inheritance
c. Autosomal dominant inheritance
d. Non-paternity

Answer 1

b. Autosomal recessive inheritance

Question 2

A disease is linked to the ABO system. The pedigree demonstrates:

a. Parental haplotye
b. Linkage disequilibirum
c. Crossing over
d. Nondisjunction

Answer 2

c. Crossing over

Question 3

A trait carried on the Y chromosome will be passed from:
a. Fathers to 50% of sons or daughters
b. fathers to 100% of sons and 50% of daughters
c. Fathers to 100% of sons and no daughters
d. Fathers to 100% of daughters and no sons

Answer 3

c. Fathers to 100% of sons and no daughters

Question 4

A man who is genotype AO married a genotype OO woman. What is the probability that their first child will be type A?
a. 12.5%
b. 25%
c. 50%
d. 75%

Answer 4

c. 50%

Question 5

Which of the following represent the biochemical structure of the H antigen on red cells?
a. Cer-Glu-GaI-GlcNac-GalNac
b. Cer-Glu-Gal-GlcNac-Gal-Fuc
c. Cer-Glu-Gal-GlcNac-Glu-Fuc
d. Cer-Glu-Gal-GlcNac-Gal-Glu

Answer 5

b. Cer-Glu-Gal-GlcNac-Gal-Fuc

Question 6

A man phenotypes A2, Le(a+b-). His saliva shows only Lea. Which of the following best represents his genotype?
a. A20, HH, Lele, Sese
b. A2A2, Hh, lele, sese
c. A20, HH, Lele, sese
d. APO, Hh, lele, Sese

Answer 6

c. A20, HH, Lele, sese

Question 7

The following Rh phenotyping results are obtained. What is the most likely genotype?
-D -C -E -c -e -f
0 + + + + 0

a. rr
b. r’r
c. r”r
d. r’r”

Answer 7

d. r’r”

Question 8

An Rh-negative woman has requested prediction of the Rh genotype of her offspring. Phenotyping results of her family shows the following results. What is the husband’s most likely Rh genotype?

Woman dce
Her husband DCce
Husband’s mother dCce
Husband’s brother Dce

a. R1r’
b. r’r’
c. R1r
d. R0r’

Answer 8

d. R0r’

Question 9

The amino acid sequence responsible for the M antigen is:
a. Leu-ser-Thr-Thr-Glu
b. Ser-ser-Thr-Thr-Gly
c. Leu-Ser-Ser-Thr-Glu
d. Thr-Ser-Thr-Leu-Gly

Answer 9

b. Ser-ser-Thr-Thr-Gly

Question 10

The antigen that occurs in approximately 20% of individuals of African ethnicity is:
a. K
b. Kpa
c. Kpb
d. Jsa

Answer 10

d. Jsa

Question 11

Finding compatible RBCs would be most difficult for patients with antibody to:
a. Vel
b. D, C, E, K
c. c, Fya
d. Wra, Hta

Answer 11

a. Vel

Anti-Vel is an extremely rare antibody. Vel is a high frequency antigen. ~1: 4,000

Question 12

The Diego blood group is of anthropological interest because:
a. Dia is a common antigen in the Caucasian population.
b. Dia is found in few African Americans.
c. Dia is more frequent in individuals of Mongolian ancestry.
d. Di(a-b-) individuals are usually Hispanic.

Answer 12

c. Dia is more frequent in individuals of Mongolian ancestry.

Question 13

The most common CH/RG phenotype is:
a. CH/RG:1, 2, -3, 11, -12
b. CH/RG:1, 2, 3, 11, 12
c. CH/RG:1, -2, 3, 11, 12
d. CH/RG:1, 2, -3, 11, 12

Answer 13

b. CH/RG:1, 2, 3, 11, 12

Question 14

Which antigen is located on the CRI protein?
a. Cra
b. Kpc
c. McCc
d. Erc

Answer 14

c. McCc