Blood Fractionation and Apheresis

Question 1

fractionation method (cold ethanol) that yielded albumin, fibrinogen, and immunoglobulins
(Plasma fractionation)

Answer 1

Edwin Cohn
(1940)

Question 2

Developed the first cell separator

Answer 2

Edwin Cohn (1951)

Question 3

established the efficacy of albumin as a component and as a treatment of shock

Answer 3

Isodor Ravdin
(1941)

Question 4

Used centrifugation technology to separate whole blood into plasma and red blood cells to perform the first reported therapeutic plasmapheresis procedure

Answer 4

A. Solomon and
J. L. Fahey (1960s)

Question 5

developed the “Latham bowl” and the first apheresis machine was introduced

Answer 5

Alan Latham (1971)

Question 6

Apheresis is used to extract one cellular component, returning the rest of the blood to the donor

Answer 6

1972

Question 7

Plasmapheresis is introduced as a means
of collecting plasma for fractionation

Answer 7

1964

Question 8

Platelet concentrates are recognized for reducing the mortality from hemorrhage in cancer patients

Answer 8

1961

Question 9

Concentrated form of Factor VIII by pooling

Answer 9

Kenneth M. Brinkhous and Dr. Edward Shanbrom (late 1960s)