Blood Anticoagulation, Preservation, and Storage Flashcards
Recommended the use of SODIUM PHOSPHATE as an anticoagulant for blood transfusion
Braxton Hicks
(1869)
First anti-coagulant discovery
1869
Reported the use of sodium citrate as an anticoagulant solution for blood transfusion
(First human transfusion using citrated blood)
Albert Hustin and Luis Agote (1914)
Determined the minimum amount of citrate used for anticoagulation and demonstrated its nontoxicity in small amounts (0.2% - safe)
Richard Lewisohn
(1915)
Found that citrated blood could be refrigerated for several days before use
Richard Weil (1915)
Introduced a citrate-dextrose solution for the preservation of blood
Francis Rous & J.R. Turner
(1916)
First transfusion of stored blood (in Word War I)
Oswald Robertson
(1916)
Robertson received the AABB Landsteiner Award as developer of the first blood bank
1958
Introduced the formula for the preservative acid-citrate-dextrose (ACD)
John Loutit and Patrick Mollison (1943)
Long-term red cell preservation by freezing
- Showed that glycerol could prevent freeze-thaw damage
Audrey Smith
(1950)
Introduced an improved preservative solution, citrate-phosphate-dextrose (CPD), which was less acidic and eventually replaced ACD as the standard preservative used for blood storage
Gibson
(1957)
Approved the use of adenine for blood preservation
US Food and Drug Administration (FDA) (1978)
Additive solutions extend the shelf life of red blood cells to 42 days
1983
Cryoprecipitates → yield high amounts of Factor VIII
Judith pool
(1965)
Development of the refrigerated centrifuge
1953
FDA requires blood bags to be labeled “paid” or “volunteer”
● Approved the use of adenine for blood preservation
1978
Additive solutions extend the shelf life of red blood cells to 42 days
1983
demonstrate the feasibility of storing platelets at room temperature, revolutionizing platelet transfusion therapy.
S. Murphy and F.
Gardner (1969)
