Blood drugs Flashcards
Platelet Inhibitors
Abciximab
Aspirin
Cilostazol
Clopidogrel
Dipyridamole
Epti fiba tide
Pra sugrel
Ticlo pidine
Tiro fiban
Anticoagulants
Arga troban
Dabi gartan
Dalte parin Enoxa parin Fonda parin ux He parin Tinza parin
War farin
Lepi rudin
Thrombolytic Agents
Alte plase
Rete plase
Tenecte plase
Streptokinase
Urokinase
Treatment of bleeding
Amino caproic acid Aprotinin Protamine sulfate Tranexamic Acid Vit K (phytonadione)
Treatment Of Anemia
Cyano Cobalamin (B12)
Erythro poietin (in renal failure anemia)
Folic Acid
Iron
Treatment of Sickle Cell Anemia
Hydroxyurea
Pentoxifylline
Voxelotor
Aspirin mechanism
Inhibits COX1 & COX2
Arachidonic Acid converts to Prostaglandin via COX enzyme
Prostaglandin converts to Thromboxane A2
Clopidogrel
Ticargrelor
Ticlopidine
Prasugrel
P2Y12 subtype ADP receptor BLOCKAGE
Abciximab
Tirofiban
Epfibetide
GP IIb/IIIa receptors blockage so platelet cannot attach to fibrinogen
Dipyridamole
Cilostazole
Inhibits phosphodiesterase which converts cAMP to AMP.
Intracellular level of cAMP⬆️ thus intracellular Ca⬇️
Also promotes vasodilation
Heparin
LMWH
Enoxaparin
Dalteparin
Antithrombin III is a naturally occurring thrombin inhibitor
These drugs bind to antithrombin III and acceleration it’s activity. Inhibits Factor Xa & thrombin.
LMWH only work on Xa
Heparin works on both.
Fondaparinux
Doesn’t bind to antithrombin III. Inhibits Xa
Apixaban
Rivaroxaban
Bind to Xa active site. Distort it.
So prothrombin isn’t converted to thrombin.
Direct thrombin inhibitors
Argatroban
Dabigatran
Desirudin
Bivalirudin
Univalent (active site binding) with thrombin.
Bivalent (active site + exosite1 binding) with thrombin.
Warfarin
Vit K is required to make
Factor VII, IX, X, & Prothrombin.
Vitamin K reduced form must be converted to Vit-K epoxide.
Via Vit-K epoxide reductase
Warfarin inhibits Vit-K epoxide reductase
SLOW slow clearance. Long duration of action. Hepatic clearance. Oral Narrow therapeutic index INR monitoring. (2 to 3 normal) Extrinsic pathway
