Blood Disorders Flashcards
In the morphological approach, anemia is classified by
the size of red blood cells
The average size of an eythrochye is reflected in
the mean corpuscular volume (MCV)
In clinical workup, the MCV will be
one of the first pieces of information available
In mean corpuscular volume (MCV) what range is considered NORMOCYTIC?
80-110
The _______ approach to anemia yields arguably the most clinically relevant classification of anemia
Kinetic
Why might the kinetic approach be the most clinically relevant classification of anemia?
Because it compares erythrocyte production (reticulocyte count) vs destruction (Elevated LDH).
Hemolytic Anemia is
Anemia involving increased destruction of Erythrocytes.
Microcytic anemia is?
Anemia marked by small erythrocyte size, (average size count)
Microcytic anemia is often the result of?
Iron Deficiency.
Pure red cell aplasia (PRCA) is technically called
Erythroblastopenia
Aplastic Anemia refers to
“inability to make mature blood cells of all types” anemia. -due to damaged
Pernicious means
highly harmful, especially in a gradual or subtle way. In this context it really means that it was once a fatal condition.
Pernicious anemia is of the __________ family.
megaloblastic (so macrocytic) family.
The fundamental alteration of anemia is (definition)
a reduced oxygen-carrying capacity of the blood resulting in tissue hypoxia.
Macrocytic anemias are also called _____________ anemias.
Megaloblastic.
Macrocytic anemias are due to
B12 deficiency usually (leading to deficient erythrocyte DNA synthesis). The result is they die young, decreasing their circulating numbers, causing anemia.
The most common type of anemia in the world is
Iron deficiency anemia.
Koilonychia is
Spoon shaped fingernails. A sign of iron deficiency anemia.
Sideroblastic Anemias are
a diverse group of anemias of varying severity. All due to inefficient iron uptake.
Sideroblastic anemias can be;
Hereditary or reversable
Phlebotomy is
The removal of blood from circulation.
NORMOcytic, NORMOchromic anemias are characterizes by
y erythrocytes that are relatively normal in size and hemoglobin content but INSUFFICIENT IN NUMBER
Clinical manifestations of anemia are:
Decreased oxygen delivery to tissues causes fatigue, dyspnea, syncope, angina, compensatory tachycardia, and organ dysfunction
