Blood Components Flashcards
What 7 information is found on a blood component label?
- Unique donor ID
- Blood type (bar code)
- Expiration
- Special testing info
- Collection facility (registration & license #)
- Name of facility that modifies original product
- Descriptive product code
An automated donation process that allows you to selectively donate only the blood components that are needed most, with the remaining blood being returned to you.
Apheresis
What is collected during an automated collection?
Power reds (2RBC), red blood cells, platelets and plasma
What are the ways to separate the components of blood from each other?
Centrifugation
Separation
Gravitational separation
What is the content of Whole Blood (WB)?
contains red cells, white cells, and platelets suspended in plasma
What an indication someone needs Whole Blood (WB)?
Symptomatic anemia with large volume deficit (trauma, surgery)
What is the storage period for all CPDA-1 blood components like WB and RBCs?
35 days
What is the storage period for ACD, CPD, CP2D Whole Blood (WB)?
21 days
What is the storage temperature for Whole Blood (WB)?
1-6C
What is the dosage for 1 WB in an adult (70kg)?
up hct 3% or hgb 1 g/dl
What are the contents of Red Blood Cells (RBC)?
Red cells
What is an indication someone needs RBC?
Symptomatic anemia, trauma, surgery
What is the storage period for ACD, CPD, CPD2 RBC?
21 days
What is the storage period for additive RBC?
42 days
What happens to RBCs if the seal is broken during processing?
RBCs must be transfused within 24 hours and new expiration date and time must be on the label and in the records
What is the storage temperature for RBCs?
1-6C
What is the dosage for RBCs for an adult (70kg)?
1 RBC, up hct 3% or hgb 1 g/dL
What is the content of Red Blood Cells, Leukocyte-Reduced (RBC-LR)?
Red cells, white cells reduced
What is the indication someone needs RBC-LR?
Symptomatic anemia, febrile reactions from leukocyte (WBC) antibodies
What is the storage period for CPDA-1 RBC-LR?
35 days
What is the storage period for additive RBC-LR?
42 days
What is the storage temperature for RBC-LR?
1-6C
What type of blood components are best for people with anemia?
Packed cells
What are the contents of Red Blood Cells, Frozen?
Deglycerolized red cells
What is the indication for RBCs, Frozen?
Symptomatic anemia
What is the freezer storage temperature and period of RBC, frozen?
-65C or below for 10 years
What is the thawed storage temperature and period for RBC, frozen?
1-6C for 24 hours
What is the dosage for adult (70kg) for Red Blood Cells, Frozen?
1 RBC, up hct 3% or hgb 1g/dL
What is the content of Fresh Frozen Plasma (FFP)?
Plasma prepared and frozen within 8 hours of WB phlebotomy & contains plasma proteins and all coagulation factors
What is the indication for Fresh Frozen Plasma?
Deficient of labile and stable plasma coagulation factors
What is the freezer storage temperature and period for Fresh Frozen Plasma?
-18C or below for 1 year
What is the thawed storage temperature & period for Fresh Frozen Plasma?
1-6C for 24 hours
What is the content of Frozen Plasma-24 hours (FP24)?
WB and apheresis plasma prepared and frozen within 24 hours of phlebotomy & contains plasma proteins and non-labile coagulation factors
What is the content of Frozen Plasma-24 Hours (PF24RT24)?
Apheresis Plasma prepared within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy & plasma proteins and non-labile coagulation factors
What is the indication of Frozen Plasma-24 Hours (FP24, PF24RT24)?
Deficient or defective plasma proteins and non-labile coagulation factors (so don’t give to a patient with coagulation issues)
What is the freezer storage temperature and period for Frozen Plasma-24 hours?
-18C or below for 1 year
What is the thawed storage temperature and period for Frozen Plasma-24 hours?
1-6C for 24 hours
What is the content of Cryopreciptated Antihemophilic Factor (AHF, Cryo)?
Cold insoluble precipitate from thawed FFP & rich in Factor VIII, XIII, vWF, and Fibrinogen
What is the indication for Cryoprecipitated Antihemophilic Factor?
- Hemophilia A
- von Willebrand’s Disease
- Hypofibrinogenemia
- Factor XIII deficiency
What is the freezer storage temperature and period for Cryoprecipitated Antihemophilic Factor?
-18C or below for 1 year
What is the thawed storage temperature and period for Cryoprecipitated Antihemophilic Factor?
RT for 6 hours or 4 hours if pooled
What is the content of Plasma Cryoprecipitate Reduced?
Plasma residual from cryoprecipitate production and refrozen within 24 hours of thawing at -18C or below & deficient in fibrinogen, Factor VIII, Factor XIII, and von Willebrand Factor (vWF)
What is the indication you should give Plasma Cryoprecipitate Reduced?
Provide clotting factors except fibrinogen, Factor VIII, Factor XIII, and von Willebrand Factor & plasma exchange for TTP
What is the freezer storage temperature and period for Plasma Cryoprecipitate Reduced?
-18C of below for 1 year
What is the thawed storage temperature and period for Plasma Cryoprecipitate Reduced?
1-6C for 5 days
What is the content for Platelets (PLT, PLC, SDP, PP)?
Thrombocytes to help stop bleeding
What is the indication you need platelets?
Low platelet count or platelet function abnormality
What is the storage temperature and period of platelets?
20-24C for a period of 5 days with gentle agitation
What is the dosage for platelets?
1 Platelet Concentrate (bag)/10 Kg body weight
What is the adult dosage for platelets?
5-6 platelet concentrates (PLT, PLC) or 1
Single Donor Platelets (SDP, PP)
What is the platelet concentrate?
1 Platelet Concentrate, up 5000-10,000/uL
What is the platelet pheresis?
1 Platelet Pheresis, up 30,000-60,000/uL
What is the content of granulocytes?
Concentrated leukocytes
What is an indication you need granulocytes?
Neutropenia (low neutrophils) with infection
What is the storage temperature and period for granulocytes?
20-24C; transfuse within 24 hours of collection
What is the function of Irradiated Components (WB, RBC, Platelets)/
Stops proliferation of White Blood Cells and treats components with WBCs
What is an indication someone needs Irradiated Components?
Prevents “graft vs host” disease in patients with immunodeficiency
What is the storage period of Irradiated Components?
Expiration date is 28 days from irradiation, but not more than the original expiration date; irradiated platelets will retain the original expiration date since it is only a 5 day product
What is the storage temperature of Irradiated Components?
Retains applicable component storage temperature
What is Pathogen Reduction Technology (PRT)?
Treatment of platelets and plasma
What is the function of Pathogen Reduction Technology (PRT)?
Reduces the infectious levels of pathogens
What are the pathogens inactivated by PRT?
Viruses (CMV, Hep, HIV), bacteria (E. coli, pneumonia), parasites, WBC (inactivation of white cell replication; alternative to irradiation)
What is Platelet Additive Solution (PAS)?
Crystalloid nutrient media
What is the point of Platelet Additive Solution (PAS)?
Replaces a portion of plasma in platelet components and lowers risk for allergic transfusion reactions (potentially mitigates against TRALI)
What tests are required for donor blood testing?
ABO (forward and reverse), DAT, IAT for Weak D, ABS, syphilis, Hepatitis, HIV, Chagas, ZIKA
What tests are optional for donor blood testing?
Antigen screening (K, Fyb, E, etc), Hemoglobin S, Anti-CMV