Blood Clotting Pathways Flashcards

1
Q

What are the 3 steps of haemostasis?

A

1- Vascular spasm
2-Platelet Plug
3-Blood Coagulation

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2
Q

Why must haemostasis be appropriately controlled?

A

1- to avoid inappropriate clot formation
2-clots must be eventually degraded
3-clots are a temporary solution

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3
Q

Explain the 1st step in haemostasis - vascular spasm.

A

muscle cells of blood vessels contract after injury and VASOCONTRICTION occurs to reduce blood flow and limit blood loss.

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4
Q

What happens to opposing endothelial surfaces in the vascular spasm stage?

A

opposing endothelial surfaces are pressed together and adhere on contact

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5
Q

How is the vascular spasm stage mediated?

A

By platelet-derived products:

Serotonin
and
Thromboxane

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6
Q

What does normal endothelium produce?

A

vasoDILATORS and
inibitors of platelet aggregation -

e.g. protaglandin and nitric oxide

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