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Medical Biochemistry > Blood Clotting Factors > Flashcards

Blood Clotting Factors Flashcards

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USMLE® Step 1 flashcards
1
Q

Substance that decreases KM of plasmin precursor, plasminogen …

A

Fibrin

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2
Q

What is the function of Aspirin?

A

Inhibition of Thromboxane A2

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3
Q

What is the function of warfarin and coumarin?

A

Inhibition of Vitamin K

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4
Q

What is the function of Heparin Sulphate?

A

Keeps platelets from activating

Anti-Coagulant

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5
Q

What is the function of Thrombomodulin?

A

Binds to activate Protein C.
Stimulated by Thrombin
(Anti-Coagulant)

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6
Q

What is the function of prostacyclin (prostaglandin i) in respect to coagulation?

A

Increase in cAMP which leads to platelet inhibition. (Anti-coagulant)

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7
Q

What is the function of Nitric Oxide in respect to coagulation?

A

Increase in cAMP which leads to platelet inhibition.

Anti-Coagulant

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8
Q

What is the function of Thromboxane A2?

A

Vasoconstriction (This leads to the release of calcium which assist in platelet activation)

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9
Q

What is essential for the functionality of factors 7 / 9 / 10?

A

Calcium
Factors 7 / 9 / 10 contain carboxyglutamate used to retain calcium. Vitamin K is essential for the functionality of carboxyglutamate.

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10
Q

What is streptokinase involved in with respect to coagulation?

A

Conversion of plasminogen to plasmin

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11
Q

Another name for glycoprotein 2 is …

A

Factor III

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12
Q

What is the function of plasmin?

A

Degradation of fibrin clots

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13
Q

A deficiency of von Willebrand factor (vWF) is also a deficiency of what factor?

A

Factor VIII

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14
Q

What is hemophilia, and what factor is considered deficient in this pathological condition?

A

Inability to form blood clots.

Factor VIII

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15
Q

What is Thrombocytopenia?

A

Insufficient platelet concentration

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16
Q

What is Ganzmann Thrombasthenia?

A

Deficiency in Glycoprotein 2 / Factor 3

17
Q

What is Prothrombin Time (PT)?

A

Measures efficiency of Extrinsic Pathway (12-16 sec)

18
Q

What is Partial Thromboplastin Time (PTT)?

A

Measures efficiency of Intrinsic Pathway (25-35 sec)

19
Q

What is Leiden’s diesease?

A

Point mutation in factor 5 making it resistant to protein C inactivation.

Medical Biochemistry (2 decks)

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