Blood Bourne Viruses Flashcards
What are viruses?
Obligate intracellular parasites without cellular structure
What do viruses consist of?
Molecule(s) of either DNA or RNA (but not both) surrounded by a protein coat
Do viruses have an envelope?
They may or may not
Where is the envelope of a virus derived from?
The plasma membrane of the host cell from which it is released
How do viruses reproduce?
They hijack the host’s mechanism for creating mRNA and production of proteins
What happens once viruses have reproduced in the host cells?
They can be released from the cell to infect other cells
How can new viruses be released from the original cell?
Can often occur by death of the infected cell
How can viruses be classified?
In a variety of ways, based on their structure
Give 7 examples of key viral classifications
Single-stranded, non-enveloped DNA viruses
Double-stranded, non-enveloped DNA viruses
Double-stranded, enveloped DNA viruses
Single-stranded, positive stand, icosahedral, non-enveloped RNA viruses
Single-stranded, positive strand, icosahedral or helical, enveloped RNA viruses
Single-stranded, negative strand, helical, enveloped RNA viruses
Double-stranded, icosahedral, non-enveloped RNA viruses
How many people does HIV infect per year around the world?
~2 million
How many new cases of HIV are there per year in the UK?
~6,000
How many people in the world have HIV?
37million
What happens if HIV is left untreated?
Most cases of HIV will progress to AIDS
How many deaths worldwide did HIV cause in 2014?
1.2million deaths
How many deaths did HIV cause in the UK in 2014?
320
How many people with HIV are there in the UK?
103,000
What % of those infected with HIV in the UK are men?
67%
What is the HIV prevalence in Leicester, compared to the UK?
3.8/1,000 in Leicester, compared to 1.9/1000 in the UK
What % of those infected with HIV are heterosexuals?
57%
What has happened regarding new diagnoses of HIV in heterosexuals since 2005?
It has decreased by 50%
How does the stage of diagnosis of HIV differ between heterosexuals and homosexuals?
> 50% of heterosexuals are diagnosed at a later stage
What is the result of heterosexuals being diagnosed with HIV at a later stage?
Worse outcome
What % of those with HIV in the UK are black African?
50-60%
What is the prevalence of HIV in IVDUs in the UK?
2/1000
What % of sexual transmissions of HIV in the UK do MSM account for?
57%
What is happening to the rate of sexual transmission of HIV by MSM?
It is increasing, whilst a decrease has been seen in every other group
What % of people living with HIV in the UK don’t know they have it?
17%
What is HIV?
A retrovirus
What does HIV do?
Infects and replicates within cells of the immune system, particularly CD4+ cells
How does HIV gain access to CD4 cells?
It binds to the receptors on the CD4 cells, and fuses with them to deposit their contents into them
What happens once HIV has deposited it’s contents into CD4 cells?
Single strands of viral RNA are then converted to double stranded DNA by reverse transcriptase
What happens once double stranded DNA has been produced from HIV RNA?
The viral DNA is combine with the cell’s down DNA by the integrase enzyme
What is the result of the combination of HIV DNA and the cells own DNA?
When the infected cell divides, the viral DNA is read and long chains of proteins are made
What happens to the proteins produced as a result of HIV DNA integration?
Sets of these viral proteins come together and push out of the cell, taking some membrane with it to form an immature virus
What happens to the immature HIV virus?
It breaks free of the cell and matures to form a working virus that can infect more cells
What is the result of the use of CD4 cells as a host by HIV?
Causes death of CD4 cells and damages the immune system
What is the result of the damage to the immune system caused by HIV?
Patients present with opportunistic infections
Give 3 examples of opportunistic infections a patient with HIV might present with
Oral candidiasis
Kaposis’s sarcoma
PCP (pneumocystis pneumonia)
What infections are HIV patients prone to in particular?
Infections from yeast, moulds, and protozoa
What happens to the levels of CD4 cells present when infected with HIV?
It alters the levels present, and this changes over time
What is the result of the altered levels of CD4 found in HIV?
Leads to altered states of health
What are the stages in a HIV infection?
Stage 1 - acute infection/seroconversion
Stage 2 - Latent infection
Stage 3 - Symptomatic infection
Stage 4 - Severe infection/AIDS
What happens in the acute infection/seroconversion state of HIV?
The body mounts an unsuccessful immune response and causes a brief fall in CD4 count
When does phase 1 of HIV infection occur?
2-3 months after exposure
What happens in the latent infection stage of HIV?
CD4 count remains high and the viral load is now
How long does the latent infection stage of HIV last?
Can last from 2 to 10 years, with some individuals never progressing from this stage
When do symptoms start to show in HIV?
If the CD4 count falls below viral load
What is the CD4 count in stage I HIV?
> 500
What is the CD4 count in stage II HIV?
<500
What is the CD4 count in stage III HIV?
<350
What is the CD4 count in stage IV HIV?
<200
Where do the symptoms of an acute HIV infection affect?
Systemic Central Mouth and throat Nose Muscles Liver and spleen Lymph nodes Skin Gastric
What are the systemic symptoms of an acute HIV infection?
Fever
Weight loss
What are the mouth and throat symptoms of an acute HIV infection?
Pharyngitis
Sores
Thrush
What are the oesophageal symptoms of an acute HIV infection?
Sores
What are the muscular symptoms of an acute HIV infection?
Myalgia
What are the liver and spleen symptoms of an acute HIV infection?
Enlargement
What are the central symptoms of an acute HIV infection?
Malaise
Headache
Neuropathy
What are the lymph node symptoms of acute HIV infection?
Lymphadenopathy
What are the skin symptoms of an acute HIV infection?
Rash
What are the gastric symptoms of an acute HIV infection?
Nausea
Vomiting
Where do the symptoms of later HIV/AIDS affect?
Brain Eyes Mouth and throat Blood Lungs Bone Heart Liver Stomach Reproductive system Body
What are the brain symptoms of later HIV/AIDS?
Cryptococcal meningitis
Toxo (toxoplasmosis)
AIDS dementia complex
What are the eye symptoms for later HIV/AIDS?
CMV (cytomegalovirus)
What are the mouth and throat symptoms for later HIV/AIDS?
Cold sores and ulcers
Thrush (oral candidiasis)
What are the blood symptoms for later HIV/AIDS?
Hyperglycaemia
Dyslipidaemia
What is dyslipidaemia?
Abnormal amount of fat in blood
What are the lung symptoms of later HIV/AIDS?
Histoplasmosis
PCP
TB
What are the bone symptoms of later HIV/AIDS?
Osteoporosis
What are the heart symptoms of later HIV/AIDS?
Heart disease
Stroke
What are the liver symptoms of later HIV/AIDS?
HCV (Hep C virus)
What are the stomach symptoms of later HIV/AIDS?
CMV
Crypto (cryptosporidiosis)
MAC (mycobacterium avium complex)
What are the reproductive system symptoms of later HIV/AIDS?
Genital ulcers HPV (human papillomavirus) and cervical cancer Menstrual problems PID (Pelvic inflammatory disease) Vaginal yeast infections
What are the body symptoms of later HIV/AIDS?
HIV wasting syndrome