Blood and Immunity Flashcards
Plasma
liquid portion of blood, 91% water, 7% proteins, 2% other solutes
Serum
plasma without clotting factors (fibrogens)
Erythrocyte
red blood cells, carry oxygen, contribute to carbon dioxide transport
Leukocyte
white blood cells in buffy coat, immune system cells (basophils, neutrophils, eosinophils, lymphocytes, monocytes)
Thrombocyte
platelets in a buffy coat. Prevent blood leaks from damaged blood vessels
Hemoglobin
carries oxygen, four heme molecules per globin
Oxyhemoglobin
hemoglobin bound by oxygen in red blood cells
Deoxyhemoglobin
oxygen released from heme at muscles or tissues, becomes this
Carbonic Acid
H2CO3, CO2 turned into this when mixed with water. equilibrates into bicarbonate (CHO3-) and hydrogen ion (H+)
Endothelial Growth Factor
attract thrombocytes to the exposed connective tissue, merge to form a plug which prevents further bleeding
Platelet Plug
the seal that is formed to maintain blood vessel integrity
Immune System
protects body from own defective cells, bacteria, viruses, other pathogens
Immune Specificity
pathogens are remembered by certain antigens
Immune Memory
remember antigens that the body has encountered, initiate corresponding immune response
Lymph Tissue
remove excess tissue fluid, transport waste materials including interstitial fluid contains waste material, filter lymph by removing microorganisms/cellular debris + other foreign matter
External Innate Immunity
first physical barrier of immune system to invading microorganisms, mucosal cells, mechanical barriers (skin, mucous membranes), chemical barriers (HCL in gastric mucosa), can’t recognize self from non-self
Internal Innate Immunity
2nd level of non-specific immunity (to pathogen), broad inflammatory response (inflammation, phagocytosis, cytokine production). can recognize ‘non-self,’ no memory. Basophils, eosinophils, neutrophils, monocytes activated. Symptoms: inflammations and fever+
Neutrophils
most abundant white blood cells, function in phagocytosis
Adaptive Immunity
exposure to an antigen triggers animals own immune response. Specificity and memory by B and T lymphocyte cells. Slower response than internal innate immune system, more specific to the pathogen and has memory. Humoral immunity and cell-mediated immunity, activated in immunization
Lymphocyte B cells
can become either plasma cells that produce antibodies or memory cells that allow the body to recognize invaders in the future and respond faster
Lymphocyte T cells
kill invaders using various methods including phagocytosis, cytotoxic T cells, release of cytokines
Antibody Production
lymphocytes in B cells for this
Humoral Immunity
part of adaptive immunity, activation of B cells and antibodies
Cell-mediated Immunity
branch of adaptive immunity, T cells activated
Passive Immunity
animal received preformed antibodies and include the passing of antibodies by the ingestion of colostrum at the time of birth or antibodies produced by another animal and transfused IV into a sick animal. Have specific memory for certain antigens of viruses, toxins, certain bacteria