Blood And Immun

Question 0

What does a myelin last turn into?

Answer 0

Progranulocyte. (Basophils neutrophils and eosinophils)

Question 1

What become progenitor cells?

Answer 1

Pluripotent hematopoietic stem cells

Question 2

How much hemoglobin does a reticulocyte contain?

Answer 2

80% mature RBC

Question 3

Requirements for RBC production

Answer 3

EPO, thyroid, bone marrow, b12 b6 protein copper and folate

Question 4

Reticulocyte a

Answer 4

Enter through sinusoids and have nuclei

Question 5

Macrocytic anemia

Answer 5

B12 and Folic Acid deficiency (DNA)

Question 6

Megaloblastic anemiA

Answer 6

Low hb/hct

Question 7

Hematocrit HCT

Answer 7

40-48% males 35-44% females

Question 8

Hemoglobin hb

Answer 8

1/3 hematocrit value

Question 9

Epo is regulated by

Answer 9

Tissue oxygenation

Question 10

How long for epo to increase rate of RBC production?

Answer 10

2-3 days

Question 11

Factors that increase RBC synthesis

Answer 11

Anemia
High altitudes
Impaired cardiac
Impaired pulmonary
Pregnancy

Question 12

Iron stores in body

Answer 12

2/3 hemoglobin 1/3 in ferritin (marrow, spleen, liver, muscle)

Question 13

Sickle cell

Answer 13

Hemoglobin s (abnormal b chains) crystallize in low O2. Suckling occurs

Question 14

Decreased RBC synthesis

Answer 14

Iron deficiency
B12 deficiency
Folic Acid def

Question 15

High rate of RBC destruction

Answer 15

Hemolytic anemia

Question 16

Granulocytea

Answer 16

Neutrophils 50-70% WBC, eosinophils 1-4%, basophils .4%

Question 17

Agranulocytes

Answer 17

Lymphocytes 20-40% monocytes 2-8%

Question 18

WBC production

Answer 18

Bone mRrow. Thymus for kids only.

Question 19

Hematopoiesis

Answer 19

Flat bones in adults. Ends of long bones ex femur and tibia for kids.

Question 20

Lymphocytes

Answer 20

B abd T cells

Question 21

Myeloid stem cells

Answer 21

Leukocytes, erythrocytes, and platelets

Question 22

Leukemia

Answer 22

> 5% blasts in BM (should be myeloid cell line)

Question 23

Where do granulocytes mature?

Answer 23

BM

Question 24

Band ces

Answer 24

Immature granulocytes (horseshoe)

Question 25

Monocytes mature?

Answer 25

In blood. Becomes macrophages in tissues. Up to 1 day in blood. Months to yrs is tissue.

Question 26

Lymphocytes that mature on bone marrow

Answer 26

B cells or NK cells

Question 27

What are immunoglobulins made by?

Answer 27

Lymphocytes

Question 28

Granulocytes

Answer 28

4-8 hrs blood 4-5 days tissue

Question 29

Colony stimulating factors

Answer 29

Regulates everything but lymphocytes (stim bone marrow)

Question 30

Neupogen

Answer 30

G-CSF

Question 31

Leukopenia

Answer 31

Bone marrow stops making WBC. Leukemia, radiation, meds.

Question 32

Leukemia

Answer 32

Uncontrolled WBC production non functional

Question 33

Lymph igneous

Answer 33

Cancerous production of lymphoids

Question 34

Myelogenous

Answer 34

Cancerous production of myeloid cells (can spread)

Question 35

Hemolytic disease in newborn

Answer 35

Mothers IgG (plasma B cells) crosses placenta & destroy fetal blood cells. Abo mild. Rh deadly.

Question 36

What produces heparin?

Answer 36

Mast cells, basophils. Anti thrombin III action

Question 37

Hemophilia A

Answer 37

Deficiency in clotting factor VIII. Males effected.

Question 38

T-pa

Answer 38

Fibrolytic in endothelial cells. Plasminogen to plasmin. Plasmin enzyme dissolves clot.

Question 39

Warfarin

Answer 39

Interferes w bit K dependent syn of CFs

Question 40

Aspirin MOA

Answer 40

Blocks Thromboxane A2 production

Question 41

Protein C deficiency

Answer 41

DVT risk. Protein C is activated by thrombin.

Question 42

Vitamin K dependent CFs

Answer 42

II VII IX X