Blood Abd Immun 2 Flashcards
Non specific defenses
Fever Inflammation Survellience (NK) Granulocytes and macrophages Cytokines Complement
IgE
Associated w allergic reactions/parasitic infection
What releases cytokines?
Macrophages and Helper B cells
What vas constricts near wound and vasodilator a around wound?
Mast cells
Fever…
Increases motility of WBC
Kills a few pathogens
Increases C8 production
What produces interferon?
Macrophages and and lymphocytes. Interferon helps w cancer and viral infections
B cells live…
Humoral immunity. Plasma cells. (Also lymphatic fluid)
T cells live …
Cell mediated immunity (pathogen in cell)
What makes antibodies
B lymphocytesp
Alternative Pathway
Less effective and slower activation of complement. Spontaneous. Triggered by pathogen
Classical Complement
Activated by Ag-Ab complex. Complement protein will bind to Ag-Ab.
Function of complement
Kill via opsonization, chemo taxis and lysis.
Bridge to acquired immunity by activating B cells & immune memory
Dispose of waste
CD3 receptor complex
All T cells
CD8 markers
Cytotoxic and Suppressor T cells only
Helper T
Activate B cyto T and macrophages and even NK cells
Anti-rejection drugs
Cyclosporine and glucocorticoids
Ppl w HIV
- 3 million, 1.6 ppl die
1. 1 in US
Sensitization
B cells bind w antibodies
Occurs within lymph node
Professional antigen presenting cells
Dendritic cells
macrophages
Certain B cells
IgM
Largest, produced in spleen, 1st responder, cont decreases as IgG increases
IgG
80%, opsonization, placenta
Interleukins
Sensitize T cells
Inflammation, mast cells
Stimulate antibody formation
TNF
Tumor necrosis factor, activate T cells and eosinophils, parasites
Stress
Interleukin 1, ATCH, glucocorticoids (mast cells inhibited), phagocytes and lymphocytes decreased response
