Blood Abd Immun 2 Flashcards

0
Q

Non specific defenses

A
Fever
Inflammation
Survellience (NK)
Granulocytes and macrophages
Cytokines
Complement
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1
Q

IgE

A

Associated w allergic reactions/parasitic infection

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2
Q

What releases cytokines?

A

Macrophages and Helper B cells

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3
Q

What vas constricts near wound and vasodilator a around wound?

A

Mast cells

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4
Q

Fever…

A

Increases motility of WBC
Kills a few pathogens
Increases C8 production

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5
Q

What produces interferon?

A

Macrophages and and lymphocytes. Interferon helps w cancer and viral infections

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6
Q

B cells live…

A

Humoral immunity. Plasma cells. (Also lymphatic fluid)

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7
Q

T cells live …

A

Cell mediated immunity (pathogen in cell)

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8
Q

What makes antibodies

A

B lymphocytesp

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9
Q

Alternative Pathway

A

Less effective and slower activation of complement. Spontaneous. Triggered by pathogen

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10
Q

Classical Complement

A

Activated by Ag-Ab complex. Complement protein will bind to Ag-Ab.

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11
Q

Function of complement

A

Kill via opsonization, chemo taxis and lysis.
Bridge to acquired immunity by activating B cells & immune memory
Dispose of waste

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12
Q

CD3 receptor complex

A

All T cells

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13
Q

CD8 markers

A

Cytotoxic and Suppressor T cells only

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14
Q

Helper T

A

Activate B cyto T and macrophages and even NK cells

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15
Q

Anti-rejection drugs

A

Cyclosporine and glucocorticoids

16
Q

Ppl w HIV

A
  1. 3 million, 1.6 ppl die

1. 1 in US

17
Q

Sensitization

A

B cells bind w antibodies

Occurs within lymph node

18
Q

Professional antigen presenting cells

A

Dendritic cells
macrophages
Certain B cells

19
Q

IgM

A

Largest, produced in spleen, 1st responder, cont decreases as IgG increases

20
Q

IgG

A

80%, opsonization, placenta

21
Q

Interleukins

A

Sensitize T cells
Inflammation, mast cells
Stimulate antibody formation

22
Q

TNF

A

Tumor necrosis factor, activate T cells and eosinophils, parasites

23
Q

Stress

A

Interleukin 1, ATCH, glucocorticoids (mast cells inhibited), phagocytes and lymphocytes decreased response