Blood and Haemopiesis Flashcards
Living components of blood
erythrocytes, leukocytes and Platelets
Non living component of blood
Plasma
Functions of Blood
Transport of nutrients/02 towards cells, waste products away from cells
Transport of hormones,humoral agents and immune cells
Maintaining homeostasis via coagulation and acting as a buffer
Erythrocytes Make up and Role
anucleate, biconcave discs containing Hb, formed in bone marrow and broken down in liver and spleen
Advantages of Biconcave Shape for Red Blood cells
Increases S.A so - more Hb, shorter diffusion distance, less likely to rupture.
Neutrophil Description
Most abundant WBC Multilobed Nucleus, granulocyte, numbers increase during acute bacterial infection Lifespan : 1-2 days
Lymphocyte
2nd most abundant
agranulocyte, present in tissues
B Cell = Antibody mediated
T Cell = Cell Mediated
Monocyte
Kidney shaped nucleus, agranulocyte,
transform into macrophages in tissues/ organs
Eosinophil
Bilobed Nucleus,
Granulocyte - large refractile granules (lysosomes)
Regulate local inflammatory responses
Basophil
Least common WBC
irregularly lobed nucleus
granulocyte - granules contain heparin and histamine
associated with inflammation and allergies
Platelets
Packets of cytoplasm budded from megakaryocyte
contain growth factors
How is Haemostais (Blood clotting) initiated?
Upon injury of endothelium, endothelial cells secrete Von Willibrand factor which initiates haemostasis mechanism
What happens in haemostasis?
Vasoconstriction occurs,
followed by platelet plug
finally clot forms once fibrin binds with cells and platelets
What is Haemopoiesis?
Blood cell formation
Where do blood cells develop from?
From Pluripotent haemopoietic stem cells in bone marrow
