Blood Flashcards
erythroctyes
red blood cells
Neutrophils
fight infection
Polymorphonuclear
Basophils
Bilobed; involved with inflammation especially regarding to allergic reactions
Eosinophils
Bilobed; Mainly involved in parasitic infections but also allergic diseases
Platelets
Involved in blood clotting
Lymphocyte
Large n Round. Fight infection
Monocyte
Kidney shaped; precursor for macrophage and osteoclasts
What are the steps of hemostasis (5)?
Constriction of smooth muscles around vessels
Constriction of vessels
Slowing of blood
Formation of platelet plug
Coagulation
How does a platelet plug form?
When an injury occurs, endothelial lining is disrupted which exposes the collagen
Platelets adhere to the collagen, releasing its contents via secretory vesicles.
Once contents are released…platelets are aggregated into a plug with ADP and other factors
Von Willebrand factor is a plasma protein that facilitates adherence of platelets to walls of damaged blood vessel.
What is the name of the factor plasma protein that facilitates adherence of platelets to walls of damaged blood vessels?
Von Willebrand factor
What differentiates a intrinsic from a extrinisic pathway for blood clotting?
Extrinsic pathway requires formation of tissue factor either thromboplastin or factor III
Thrombin converts ____ to ___ which functions as a ___
Fibrinogen to Fibrin; mesh-work which platelets, RBCs and plasma are entrapped to form an actual clot
____ converts Prothrombin to Thrombin
Factor VIII
Thrombin plus Ca creates two products
Fibrin and Factor VIII
Major Difference between Intrinsic and Extrinsic Pathway
Extrinsic is faster with less activations and results from trauma
Intrinsic is slower and requires more factor activation
