Hematopoeisis Flashcards
Name the granulated leukocytes
Basophils, Eosinophils and Neutrophils
Named the non-granulated leukocytes
Monocytes and lymphocytes
What are the characteristics of hematopoietic stem cells?
Pluripotent
Can Self-Renew
Produce myeloid and lymphoid stem cells
Recognized by cell surface markers
What are the five kinds of colony-forming units?
Erythroid, Megakaryocyte, Basophil, Eosinophil, Granulocyte-Macrophage
____ has an end product of RBCS
____ has end product of platelets
____, ____ and ___ has end product of WBS
Erythoid
Megakaryocyte
Basophil, Eosinophil and Granulocyte Macrophage
____ is the ferritin bound transferrin which moved into the cytosol with assistance of a receptor. ____ is the transferrin without ferritin which travels back to the plasma membrane for recycling.
Ferrotransferrin
Apoferritin
What are the three main groups of hematopoietic growth factors?
Colony
Erythropoietin/Thrombopoietin
Cytokines
What are examples of cytokines involved in hematopoeisis?
Interleukin-3
GM-CSF
Fit-3 Ligand
Kit Ligand
All growth factors are produced by?
Endothelial cells
Granulocytopoeisis and Monocytopoeisis are involved in hematopoiesis for which type of growth factors?
Colony growth factors
Erythopoitin involved in
proliferation and differentiation into proerythroblasts
Thrombopoietin involved in
direct formation of megakaryoblasts
Cytokines involved in
mediating positive and negative effects on cellular quiescence, apoptosis, proliferation and differentiation. Involved in activating certain signal pathways as well.
