Blood Flashcards
Blood matrix
Plasma
Blood formed elements
Erythrocytes, leukocytes, platelets
Amount of plasma in hematocrit
55%
Amount of buffy coat in hematocrit
1% and comprised of leukocytes and platelets
Amount of erythrocytes in hematocrit
45%
Define plasma
Straw colored sticky fluid that is 90% water with over 100 dissolved so lutes such as hormones wastes and proteins
Albumin
Makes up 60% of plasma proteins and functions as a carrier of other molecules, blood buffer and contributes to plasma osmotic pressure
RBC function
Respiratory gas transport
Hemoglobin
Binds reversibly with oxygen comprised of four polypeptide chains with a heme group attached to each one
Anemia
Blood has low O2 carrying capacity and could be caused by blood loss, not enough RBCs being produced or too many being destroyed
Polycythemia Vera
Bone marrow cancer leading to excess RBCs
Secondary polycythemia
Caused by low o2 levels like increased altitude or increased EPO production
Blood doping
Artificially injecting EPO or removing blood and reinfusing before an event
Leukocyte function
Defense agains disease
Diapedesis
Normal process of WBC leaving blood vessels to fight invaders in tissue
Granulocytes
Neutrophil, eosinophil, basophils
Agranulocytes
Lymphocyte and monocytes
Overproduction of abnormal WBC
Leukemia and mononucleosis
Abnormally low WBC count
Leukopenia, which can be drug induced by anticancer drugs or glucocorticoids
Platelet
Fragments of larger megakaryocyte
Platelet function
Form temporary platelet plug that helps seal breaks in blood vessels
Whole blood transfusion
Only used when blood loss is rapid and substantial
Agglutinins
Pre formed anti A or anti B antibodies
Antigen or agglutinogen
What immune system uses to identify blood cells