Blood Flashcards
Cardiovascular system is made up of what?
Blood
Blood vessels
Heart
2 components of blood
Plasma
Formed elements
Whole blood
Both plasma and formed elements
Normal pH in blood
7.35-7.45
slightly basic
Hypovolemic
Low blood volumes
Normobolemic
Normal blood volumes
4-6L for males
4-5L for females
about a gallon of blood in the body
Plasma
Makes up 55% of whole blood volume (largest portion of whole blood)
Consists of - 92% water
- 7% proteins
- 1% other solutes
Formed elements
45% of whole blood
Consists of: - <0.1% platelets
- <0.1% Leukocytes
- 99.9% Erythrocytes
Leukocytes
White blood cells
Erythrocytes
Red blood cells
Buffy coat
The layer of white blood cells when whole blood is separated
Interstitial fluid
The fluid outside the capillaries
Does not have proteins
Able to move the O2 and CO2 from the cells to the blood
Plasma proteins
Albumin
Globulins
Fibrinogen
Albumin
60% of plasma proteins
Contributes to osmotic pressure, transports fatty acids and steroids
Globulins
35% of plasma proteins
Act as immunoglobulins (antibodies)
Act as transport proteins
Fibrinogen
4% of plasma proteins
Involved in blood clotting, largest of the proteins
Biconcave disc
The shape of a red blood cell
This shape has more surface area
Structure of RBC
Biconcave disc
Thin central region
About 7.7 microns in diameter, capillaries are about 8 microns wide
Lack cell organells
Lack nucleus, cant live very long
Rouleau
Stack of RBC or WBC that look like a stack of coins
Does not prevent the cells function
Does not block capillaries
RBC life span
Only live for about 120 = 4 months
No nucleus to allow for more flexibility and more room for hemoglobin
No mitochondria because that uses O2 which would make RBC less efficient
Hemoglobin
Hemoglobin has 4 polypeptide subunits
Each subunit contains a Heme
Heme is a porphyrin ring
In the center of the Heme is iron
O2 connects to the iron
CO2 connects to Polypeptide
Hematocrite
The percentage of whole blood occupied by formed elements
Really only looks at RBC since WBC is less than 0.1%
Agglutinogen
The marker on red blood cells to detirmine what blood type you have
Agglutinin
Aka antibodies
The maker in the plasma to fight against blood that isn’t yours or your blood type
Causes the bad blood to clump like a clot
Leukocytes: 2 classes
Granulocytes
Agranulocytes
Hemocytometer
Total WBC count
Leukopenia
Low WBC count
Leukocytosis
Elevated WBC count
Differential count
Performed to determine which of the specific leukocytes is in excess or deficent
Diapedesis
Leukocytes can leave the blood stream through the pores to get to an infection in the body
Chemotaxis
Draws leukocytes toward the invading agent
Megakaryocytes
Platelets come from this cell
Thrombocytopenia
Lower than normal number of platelets
Thrombocytosis
Higher than normal number of platelets
Hemopoiesis
Blood formation
Hemostasis
Stoppage of bleeding
- Vascular spasm, shrinks hole in the vessel
- Platelets arrive at site of injury and stick to explosed collagen fibers to form plug
- Coagulation phase, inavtive proteins activate to help form the blood clot