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Drug Action I > Block 4: Fluid Imbalances Phys > Flashcards

Block 4: Fluid Imbalances Phys Flashcards

1
Q

What is homeostasis?

A

Maintenance of a consistent fluid and electrolyte adjustment

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2
Q

What are electrolytes?

A

Any substances that dissociate into ions in water

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3
Q

How does excess fluid affect vitals?

A
  1. Increases BP
  2. Edema
  3. Fluid accumulation in lungs
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4
Q

How does fluid deficit affect vitals?

A

↑ HR and ↓ BP

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5
Q

What is the primary anion in the ECF?

A

Chloride

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6
Q

Chloride is proportional to ___ and inversely related to ___

A

Na+, HCO3-

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7
Q

What are the biological functions of chloride?

A
  1. Maintenance of ECF osmolarity and acid-base regulation
  2. Component of HCl
  3. Essential for carbon dioxide transport
  4. Found in cerebrospinal fluid, bile, and pancreatic juices
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8
Q

Abnormally high plasma concentration of chloride is called ___?

A

Hyperchloremia

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9
Q

What can cause hyperchloremia?

A

1.Metabolic acidosis
2. Water loss and dehydration
3. Hypernatremia and PTH
4. Hyperkalemia

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10
Q

What are the clinical manifestations of hyperchloremia?

A
  1. Dehydration and symptoms
  2. Similar symptoms of hypernatermia
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11
Q

How does hyperchloremia → metabolic acidosis and hyperkalemia?

A
  1. EC H+ → IC
  2. Cl- remains in EC
  3. K+ in IC → EC
  4. No tendency towards hyperkalemia occurs in normochloremic metabolic acidosis → anions enter ICF
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12
Q

Abnormally low plasma concentration of chloride ions is ___?

A

Hypochloremia

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13
Q

What are the causes of hypochloremia?

A
  1. Loss of GI secretion
  2. Alkalosis (↑ bicarb)
  3. Volume depletion (burns, diuretics)
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14
Q

What are the clinical manifestations of hypochloremia?

A
  1. Similar to hyponatremia
  2. Cerebral edema
  3. HA, weakness, N, weight gain
  4. Shallow respirations
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15
Q

When do serum chloride levels decrease?

A

Volume depletion → hypovolemia → Activation of RAAS → ↑ Angiotensin II → ↑ aldosterone → ↑ K+ secretion → alkalosis and chloride depletion → failure of pendrin, a chloride/bicarbonate anion exchanger in the collecting duct

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16
Q

What would hypochloremia look like in labs?

A
  1. Low sodium levels
  2. Elevated BUN:CR with GI loss and burns
  3. Metabolic alkalosis
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17
Q

What are the biological functions of potassium?

A
  1. Regulates ICF osmolarity
  2. RMP
  3. Na+/K+ pump
  4. Buffering mechanism
  5. Facilitates glycogen storage in liver and skeletal muscle cells
  6. Osmotic pressure in the ICF
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18
Q

Describe the mechanism that increases K+?

A
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19
Q

Abnormally high plasma concentration of potassium ions is ___?

A

Hypoerkalemia

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20
Q

What are the complications of hyperkalemia?

A
  1. Stresses the CV system → lethal arrhythmias
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21
Q

What can cause hyperkalemia?

A
  1. Oversupplematation
  2. Renal failure
  3. Tissue trauma and breakdown
  4. Hypoxia
  5. Acidosis
  6. Insulin deficiency
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22
Q

What are the clinical manifestations of hyperkalemia?

A
  1. Muscle weakness or paralysis
  2. Dysrhythmias
  3. Heart block
  4. Cardiac arrest
  5. Neuromuscular irritability, extreme paralysis, anxiety
  6. N/V/D
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23
Q

What would hyperkalemia look like in labs?

A
  1. Elevated BNP, BUN, and Cr
  2. Decreased serum cortisol
  3. ECG abnormalities
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24
Q

Abnormally low plasma concentration of potassium ions is ___ which can lead to ___?

A

Hypokalemia, cardiac arrhythmias

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25
Q

What can cause hypokalemia?

A
  1. Decreased K+ intake
  2. Incomplete K+ replacement
  3. GI loss
  4. Fluid overload
26
Q

Clinical manifestations of hypokalemia?

A
  1. Low serum K+
  2. Cushing disease
  3. GI loss
  4. V fib
  5. Cardiac arrest
27
Q

Labs of hypokalemia?

A

Elevated BNP, BUN, and creatinine levels in heart or renal failure.

Electrocardiogram abnormalities:
Flattened T wave.
U wave development.
Cardiac arrest in severe cases.

28
Q

What are the forms of calcium?

A

Ionized (most significant), Portein-bound

29
Q

Fraction of Ca2+ found in blood?

30
Q

What are the biological functions of Ca2+?

A
  1. Coagulation
  2. Muscular contraction
  3. Cellular electrophysiology and membrane potential.
  4. Acts as a second messenger in hormonal and neurotransmitter pathways.
31
Q

Describe the mechanism of Ca2+ increasing

32
Q

What are the clinical manifestations of hypercalcemia?

A
  1. Cardiac, musculoskeletal, and neuromuscular effects → morbidity and mortality.
  2. Muscle weakness
  3. Decreased excitability of muscles and nerves from decreased Na
33
Q

Labs regarding hypercalcemia?

A
  1. Elevated PTH
  2. Elevated Vit D
  3. Evaluate TSH, T3, and T4
  4. Shortened QT interval, shortened ST segment, various tachyarrhythmias.
34
Q

Abnormally low plasma concentration of calcium ions is ___ common in ____

A

Hypocalcemia; renal failure patients

35
Q

What causes hypocalcemia?

A
  1. Hypoparathyroidism
  2. Parathyroid gland removal
  3. Hypomagnesemia, hyperphosphatemia, hypoalbuminemia
  4. Vitamin D deficiency
  5. Pancreatitis
  6. Alkalosis
36
Q

Clinical manifestations of hypocalcemia?

A

CNS and neuromuscular excitability
1. Chvostek sign
2. Trousseau sign
3. Ventricular dysrhythmias
4. Decreased blood pressure
5. Muscle and intestinal cramping
6. Hyperactive bowel sounds
7. Osteoporosis

37
Q

What is a chvostek sign?

A

Tapping on facial nerve below temple to elicit twitch or spasm of the lower lip on ipsilateral side of tapping

38
Q

What is Trousseau sign?

A

Occluding arterial blood flow of the arm for 5 minutes (typically with a blood pressure cuff), eventually causing contraction of the arm and hand

39
Q

Calcium has an inverse relations with ____

A

Phosphorus corresponding with hypomagnesemia and hyperphosphatemia.

40
Q

Biological functions of phosphorus?

A
  1. Buffer in acid–base regulation.
  2. Component in bone and ATP formation.
  3. Involved in glucose, fat, and protein metabolism
  4. Maintains control of calcium and phosphate concentrations and vitamin D regulation
  5. Involved in red blood cell, white blood cell, and platelet function
41
Q

Abnormally high plasma concentration of phosphate ions is ____?

A

Hyperphosphatemia

42
Q

What are the causes of Hyperphosphatemia?

A

Chronic renal failure

Respiratory acidosis, metabolic acidosis, hypocalcemia, vitamin D excess, chemotherapy

43
Q

Clinical manifestations of hyperphosphatemia?

A
  1. Hypocalcemia
  2. Paresthesias
  3. Muscle weakness
  4. N/V
  5. Tetany
  6. Decreased BP
  7. Cardiac dysrhythmias
  8. Both Chvostek and Trousseau signs can be elicited
44
Q

Labs of hyperphosphatemia?

A

In chronic renal failure:
Elevated BUN and creatinine levels
Elevated PTH
Decreased calcium levels

metabolic or respiratory acidosis

45
Q

Abnormally low plasma concentration of phosphate ions is ___?

A

Hypophosphatemia

46
Q

What causes of hypophosphatemia?

A
  1. Malnutrition
  2. Heat stroke
  3. Respiratory alkalosis
  4. Major burns
  5. HyperPTH
  6. Chronic diarrhea
  7. Vitamin D deficiency
47
Q

Clinical manifestation of hypophosphatemia?

A
  1. hypercalcemia
  2. Red blood cell and platelet dysfunction, bleeding disorders
  3. Impaired white blood cell function
  4. Neuromuscular dysfunction
  5. Altered mental status
  6. Excessive bone resorption
  7. Respiratory failure
48
Q

What are the presentation of hypophosphatemia in malnutrition?

A

Patient can be cachetic and have low serum albumin and pre-albumin levels

Respiratory alkalosis

49
Q

What are the presentation of hypophosphatemia in hepatic encephalopathy?

A

Liver enzymes and serum ammonia can become elevated

50
Q

What are the presentation of hypophosphatemia in hyperPT?

A

PTH hormone levels can be elevated

51
Q

second most common intracellular cation after potassium

52
Q

How much of Mg is in ECF?

A

2% most are found in bone

53
Q

Biological function of Mg2+?

A
  1. Inhibits Ca2+ release from SR
  2. Cofactor in enzymatic reactions
  3. Plays role in ATP generation, DNA replication, and mRNA production and translation
  4. Prevents potassium from exiting cardiac cells
  5. Smooth muscle relaxant
  6. Neuromuscular integrity
54
Q

How does Mg regulate PTH?

A
  1. required for the production and release of PTH, so when magnesium is too low, insufficient PTH is produced, and blood calcium levels are also reduced (hypocalcemia)
  2. hypoparathyroidism (with hypocalcemia) can be caused by abnormally high levels of magnesium
55
Q

Abnormally high plasma concentration of magnesium ions is ?

A

Hypermagnesemia

56
Q

What are the causes of hyper magnesia?

A

Renal failure

magnesium-containing antacids

57
Q

What are the contributing factors of hyper magnesium?

A
  1. Laxative use
  2. Increased dietary intake
  3. Lithium toxicity
  4. Burns, trauma, shock
58
Q

What are the clinical manifestations?

A
  1. Cardiac abnormalities
  2. Hypotension
  3. Confusion, lethargy, coma
  4. Shallow respirations
  5. Decreased deep tendon reflexes
  6. Decreased level of consciousness
59
Q

Abnormally low plasma concentration of magnesium ions is ?

A

Hypomagnesemia

60
Q

What causes hypomagnesemia?

A
  1. Excessive alcohol intake
  2. Hypoalbuminemia
    Associated with:
    Hypocalcemia: Due to decreased PTH secretion.
    Hypokalemia: Due to urinary potassium wasting.

Reduced inhibition of the renal outer medullary potassium (ROMK) channel that secretes K+

61
Q

What are the clinical manifestations of hypomagnesimia?

A
  1. Neuromuscular excitability
  2. Hypokalemia
  3. Hypocalcemia, hypoparathyroidism, PTH resistance, decreased synthesis of calcitriol.
  4. Cardiovascular sequelae most worrisome.

Drug Action I (32 decks)

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