Black 4: Vaptans

Question 1

What are the vasopressins and what do they do?

Answer 1

1. Desmopressin: angonist
2. Conivaptan: antagonist
3. Tolvaptan: antagonist

Question 2

What are the endogenous vasopressin?

Answer 2

1. ADH
2. Arginine vasopressin (AVP)

Question 3

Where are VP receptors and what is their MOA when activated?

Answer 3

V1 and 2 are found on the peripheral and renal

Question 4

What is the indication of vasopressin?

Answer 4

Used to treat central diabetes insidious

vWD by increases release of vonWillibrand factor

Question 5

Why is vasopressin even as an injectable?

Answer 5

Mimics an endogenous substrate

Question 6

What is diabetes insipidus?

Answer 6

Extreme urination, thirst, bed-wetting
Desmopressin is used

Question 7

Brand name of desmopressin acetate?

Answer 7

DDAVP

Question 8

How does DDAVP differ from Vasopressin

Answer 8

Deaminated Css

Froms a more acid stable structure → more oral bioavailability

Question 9

Brand name of Conivaptan?

Answer 9

Vaprisol

Question 10

What are the indications for Vaprisol

Answer 10

Conivaptan is a V1a and 2 antagonist used for hyponatremia

Question 11

CI with Conivaptan?

Answer 11

Decompensated CHF

Question 12

How is conivaptan formulated?

Answer 12

Formulated as injectable with 5% Dextrose → hospital based formulation only

Question 13

Tolvaptan brand name?

Answer 13

Jynarque and Samsca

Question 14

MOA of Tolvaptan? Indication? Formulations?

Answer 14

Selective V2 antagonist

Hyponatremia

PO