Block 3: AIDS MCC Opportunistic Infections

Question 1

At a level of less than 500, you start to see

Answer 1

Mostly skin infections

Question 2

At a level of less than 200 you start to see

Answer 2

systemic infections (full blown AIDS)

Question 3

MC AIDS defining infection

Answer 3

Pneumocystis jiroveci pneumonia (PCP) Fungal Infection

Question 4

MC overall fungal infection

Answer 4

Candida (oral thrush) Fungal

Question 5

MC fungal CNS infection**

Answer 5

Cryptococcus (Meningitis) Fungal Infection

Question 6

MC Opportunistic Bacterial Infections

Answer 6

Mycobacterium avium intracellulare complex (MAC):

GI tract and lung infections

Disseminated infections

Acid fast Bacilli

Bartonella henselae:

Bacillary angiomatosis (angiomatous skin lesions)

Gram negative rod

Question 7

MCC of blindness in AIDS

Answer 7

CMV

Retinitis:
MCC of blindness in AIDS
Esophagitis, colitis (Diarrhea)
Cholecystitis *

Question 8

MC Cancer Causing; there are 2

Answer 8

Oral hairy leukoplakia (EBV aka Epstein Barr virus)
Most people get infected with EBV in their lifetimes and virus establishes latency inside some cells
Immune system keeps it in check (equilibrium), so when enough T-cells are destroyed, this virus can reactivate
White coating, not scrapable
As T cells drop further, EBV reactivation can also lead to Burkitt’s lymphoma

Question 9

MC Cancer Causing; there are 2

Answer 9

Kaposi’s sarcoma ***
MC malignancy

HHV-8 (herpes family)
Enveloped dsDNA

Question 10

MCC of focal ring lesions in AIDS

Answer 10

CNS toxoplasma

Question 11

MC pathogen in diarrhea

Answer 11

Cryptosporidium