Block 2 Lecture X -- Emerging Drugs

Question 1

What is the indication for sofosbuvir (Sovaldi)?

Answer 1

HCV

Question 2

What is the mechanism of sofosbuvir (Sovaldi)

Answer 2

nucleotide analog RNAP Inhibitor (NS5B)

Question 3

What is the indication for dimethyl fumarate (Tecfidera)?

Answer 3

refractory MS

Question 4

What is the mechanism for dimethyl fumarate (Tecfidera)?

Answer 4

Nrf2 (nuclear factor [erythroid-derived 2]-like 2) activator

– upregulates Nrf2 to prevent oxidative stress with inflammation in MS

Question 5

What is the indication for ibutinib (Imbruvica)?

Answer 5

mantle cell lymphoma & chronic lymphcystic leukemia

Question 6

What is the mechanism of ibrutinib (Imbruvica)?

Answer 6

selective & covalent Bruton’s tyrosine kinase (BTK) inhibitor

Question 7

What is the indication for bortezomib (Velcade)?

Answer 7

multiple myeloma

Question 8

What is the mechanism of Bortezomib?

Answer 8

proteasome inhibitor

Question 9

What is the indication for carfilzomib (Kyprolis)?

Answer 9

refractory multiple myeloma

Question 10

What is the mechanism of carfilzomib (Kyprolis)?

Answer 10

proteasome inhibitor

Question 11

What is the mechanism for MTX?

Answer 11

DHFR inhibitor

Question 12

What is the mechanism of 5-FU?

Answer 12

5F-dUMP pyrimidine analog inhibits thymidylate synthetase (TS)

Question 13

What is the mechanism of eniluracil?

Answer 13

Dihydropyrimidine dehydrogenase (DPD) inhibitor