Block 1 - Anatomy - Thorax - Gray's Review Flashcards
A 2-day-old newborn is diagnosed with transposition of the great arteries. Which structure is primarily responsible for the division of the truncus arteriosus into the great arteries?
A. Septum secundum
B. Septum primum
C. Bulbar septum
D. Aorticopulmonary septum
E. Endocardial cushions
D. Aorticopulmonary septum
What defect accounts for 25% of all congenital heart defects?
Ventricular septal defect
(most commonly membranous)
What heart defect can keep a child with transposition of the great arteries alive until the transposition is corrected?
A patent ductus arteriosus
(to allow mixing of oxygenated and unoxygenated blood)
A 32-year-old woman in her third trimester of pregnancy is undergoing a routine ultrasound examination.
The examination of the fetus reveals enlarged and echogenic lungs, an inverted diaphragm, and fetal ascites. Which condition is best characterized by these signs?
A. Laryngeal atresia
B. Tracheal atresia
C. Polyhydramnios
D. Lung hypoplasia
E. Oligohydramnios
A. Laryngeal atresia
Ultrasound examination of a fetus with laryngeal atresia might show what signs?
Enlarged and echogenic lungs, an inverted diaphragm, fetal ascites
A child presents with a loud S1 and a wide, fixed-split S2. What is the likely diagnosis?
Atrial septal defect
What heart murmur indicates an atrial septal defect?
A loud S1 and a wide, fixed-split S2
For what type of heart defects are children with Down syndrome especially at risk?
Atrial and ventricular septal defects
(endocardial cushion defects)
(especially septum-primum atrial defects)
Tetralogy of Fallot and truncus arteriosus are both associated with what genetic predisposition?
22q11 deletions
What heart defects are associated with 22q11 deletions?
Tetralogy of Fallot and truncus arteriosus
Which pharyngeal arches lead to the development of the portions of the aorta that may become congenitally coarcted?
The 3rd, 4th, and 6th arches
What primordial structure must fail to develop in order for a tracheoesophageal fistula to form?
The tracheoesophageal septum
What type of atrial septal defect can occur along the junction with the superior vena cava?
A sinus venosus ASD
Where can sinus venosus atrial septal defects be found?
Close to the entry of the superior vena cava
Failure of fusion of the lateral folds during development can lead to what congenital heart defect?
Ectopia cordis
(the heart is located outside the chest wall)
What is ectopia cordis?
A congenital defect in which the heart is located outside the body cavity.
(due to failure of the lateral folds to fuse during development)
A newborn baby is diagnosed with eventration of the diaphragm. In this condition, half of the diaphragm ascends into the thorax during inspiration, while the other half contracts normally. What is the cause of this condition?
A. Absence of a pleuropericardial fold
B. Absence of musculature in one half of the diaphragm
C. Failure of migration of diaphragm
D. Failure of the septum transversum to develop
E. Absence of a pleuroperitoneal fold
B. Absence of musculature in one half of the diaphragm
What structure, in particular, should a surgeon be careful not to disrupt in closing a ventricular septal defect?
The right bundle branch
If a patient with retrosternal chest pain (that radiates to the left arm) can relieve some of the pain by leaning forward, what would that indicate?
This is a pericardial friction rub, likely due to pericarditis
What three nerves are most at risk for damage during a mastectomy?
The long thoracic nerve, the intercostobrachial nerve, and the thoracodorsal nerve.
The intermediolateral horns of the spinal cord at levels T5 - T9 contain cell bodies for neurons innervating what region of the body?
To what kind of nerves do these cell bodies belong?
Abdominal organs;
sympathetic preganglionic nerves
The intermediolateral horns of the spinal cord at levels T1 - T4 contain cell bodies for neurons innervating what region of the body?
To what kind of nerves do these cell bodies belong?
The upper limbs and thoracic cavity;
sympathetic preganglionic nerves
What nerve carries the cardiac sympathetic efferent fibers from the sympathetic ganglia to the thoracic viscera and visceral afferent fibers for pain from these organs?
The cardiopulmonary splanchic nerves
For what is the cardiopulmonary splanchnic nerve responsible?
The cardiac sympathetic efferent fibers;
the visceral afferent fibers for the thoracic organs
Which nerve carries pericardial sensation (especially pain) to the CNS?
The phrenic nerve
Which nerve is responsible for innervation of the skin on the medial surface of the arm?
(the inner aspect of the arm and axilla)
The intercostobrachial nerve
A 2-day-old newborn male is admitted to the pediatric intensive care unit with cyanosis and tachypnea.
Cardiac ultrasound (echocardiography) and magnetic resonance imaging (MRI) examinations reveal totally anomalous pulmonary connections. Which of the following embryologic events is responsible for this malformation?
A. Abnormal septation of the sinus venosus
B. Abnormal development of the septum secundum
C. Abnormal development of the left sinus horn
D. Abnormal development of the coronary sinus
E. Abnormal development of common cardinal vein
A. Abnormal septation of the sinus venosus
A 4-year-old girl is admitted to the hospital with high fever. Staphylococcus aureus is isolated from her blood cultures and antibiotic therapy is initiated.
A loud, harsh murmur is heard on auscultation. A chest radiograph shows prominent pulmonary arteries. Echocardiography shows all the valves to be normal. Which congenital heart disease most likely explains these findings?
A. Atrial septal defect
B. Tetralogy of Fallot
C. Coarctation of the aorta
D. Patent ductus arteriosus
E. Aortic atresia
D. Patent ductus arteriosus
A 3-day-old infant is admitted to the cardiology unit with severe cyanosis.
During echocardiographic examination a right-to-left shunt is identified. Which of the following conditions will most likely produce this type of shunt?
A. Interatrial septal defect
B. Interventricular septal defect
C. Patent ductus arteriosus
D. Corrected transposition of the great arteries
E. Common truncus arteriosus
E. Common truncus arteriosus
- (failure of septation into the aorta and pulmonary trunk;*
- options* A - C would all result in left-to-right shunting;
- option D is a corrected pathology)*
A 4-day-old infant is admitted to the pulmonary unit suffering from dyspnea and cyanosis.
Radiologic examination revealed a left hypoplastic lung and herniation of the abdominal intestines into the left thoracic cavity. Which of the following embryologic structures most likely failed to develop properly?
A. Septum transversum
B. Pleuroperitoneal membrane
C. Tracheoesophageal septum
D. Laryngotracheal groove
E. Foregut
B Pleuroperitoneal membrane
A 2-day-old infant is diagnosed with incomplete division of the foregut into respiratory and digestive portions. Which is the most common congenital condition characteristic of this description?
(Note: tracheoesophageal fistula is the most common of these conditions in general)
A. Esophageal atresia
B. Esophageal achalasia
C. Tracheoesophageal fistula
D. Congenital diaphragmatic hernia
E. Esophageal fistula
A. Esophageal atresia
What major vein is at risk for accidental damage during a tracheotomy when performed on young children?
(vertical incision along anterior neck to expose and puncture the cricothyroid membrane to secure the airway)
The left brachiocephalic v.
What is another name for the cardiopulmonary artery?
Thoracic visceral a.
What nerve innervates the fibrous and parietal pericardium?
What does this mean for pain during pericardial effusion?
The phrenic nerve;
The phrenic nerve contains sensory nerve fibers from C3 to C5, spinal nerve levels that also supply the skin of the shoulder area; therefore, pain carried by the phrenic nerve may be referred to the shoulder.
A 39-year-old man is admitted to the hospital with a complaint of severe retrosternal pain that radiates to the left shoulder. The pain is relieved by leaning forward.
Auscultation reveals a pericardial friction rub, leading to a diagnosis of pericarditis. Which of the following nerves is responsible for the radiating pain to the shoulder?
A. Intercostobrachial
B. Phrenic
C. Long thoracic
D. Greater thoracic splanchnic
E. Cardiopulmonary
B. Phrenic
A 62-year-old patient is admitted to the hospital with a complaint of suddenly occurring, tearing pain radiating to his back. A CT examination reveals that the patient has an aortic aneurysm. An urgent placement of an endovascular stent-graft is performed.
Which of the following nerves are most likely responsible for the tearing sensation radiating to his back?
A. Somatic afferent
B. Thoracic visceral afferent
C. Sympathetic postganglionics
D. Sympathetic preganglionics
E. Parasympathetic afferent
B. Thoracic visceral afferent
What two valves could potentially be responsible for an abnormally loud S1 heart sound?
Tricuspid or mitral
What is another name for the LAD artery?
Anterior interventricular a.
How long is the left main coronary artery in most hearts?
Very short (~1 cm) before branching into the circumflex and LAD
Are the branches of the coronary arteries end arteries?
Are anastomoses possible and/or present between them?
No (collaterals are present - an end artery is an artery that is the sole provider of blood flow to a region - also known as a ‘terminal artery’);
yes
What is another name for an end artery?
What differentiates these arteries from others?
Terminal artery;
they are the sole blood supply to a final area of tissue (no collaterals or anastomoses)
If the atria are contracting normally but both ventricles are undergoing arrhythmias, what structure of the heart may be damaged?
The Bundle of His
What type of fiber makes up the Bundle of His and bundle branches?
Purkinje fibers
Which artery supplies the anterior right ventricle?
Which artery supplies the posterolateral right ventricle?
Which artery supplies the right atrium and SA node?
Right conus a.;
acute marginal a.;
posterior descending a.
What region of dense connective tissue between the tricuspid and mitral valves allows for passage of the Bundle of His from the AV node to the ventricles?
The right fibrous trigone
What structure passes through the right fibrous trigone?
The atrioventricular Bundle of His
A 72-year-old man is admitted to the hospital with severe chest pain. ECG examination provides evidence of severe myocardial infarction of the lower part of the muscular interventricular septum.
The function of which of the following valves will be most severely affected?
A. Pulmonary
B. Aortic
C. Tricuspid
D. Mitral
E. Eustachian
C. Tricuspid
Which heart valve would be most affected by occlusion of an artery feeding the muscular interventricular septum?
The tricuspid
A 69-year-old woman with advanced stage of laryngeal cancer has a tracheostomy and needs to be tube fed. A nasogastric tube is inserted.
What is the last site at which resistance would be expected as the tube passes from the nose to the stomach?
A. Pharyngoesophageal junction
B. Level of the superior thoracic aperture
C. Posterior to the aortic arch
D. Posterior to the left main bronchus
E. Esophageal hiatus of the diaphragm
E. Esophageal hiatus of the diaphragm (at T10)