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Biochemistry > Block 1 > Flashcards

Block 1 Flashcards

0
Q

What is riboflavin?

A

Vitamin B2

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1
Q

What is thiamin?

A

Vitamin B1

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2
Q

What is pyridoxine?

A

Vitamin B6

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3
Q

What is nicotinic acid?

A

Niacin

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4
Q

What is thiamin’s coenzyme?

A

Thiamine pyrophosphate

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5
Q

What is riboflavin’s coenzyme?

A

Flavin adenine dinicleotide (FAD)

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6
Q

What is pyrodoxine’s coenzyme?

A

Pyridoxal phosphate

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7
Q

What is nicotinic acid’s coenzyme?

A

Nicotinamide adenine dinicleotide (NAD+)

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8
Q

What is the reaction type of thiamin?

A

Aldehyde transfer, forms covalent intermediate with keto groups

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9
Q

What is the reaction type of riboflavin?

A

Oxidation-reduction

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10
Q

What is the reaction type of pyridoxine?

A

Group transfer to or from amino acids, forms covalent intermediate with amino groups

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11
Q

What is the reaction type of nicotinic acid?

A

Oxidation-reduction

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12
Q

What is the consequence of thiamin deficiency?

A

Beriberi (weight loss, heart problems, neurological dysfunction)

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13
Q

What is the consequence of riboflavin deficiency?

A

Cheliosis and angular stomatitis (lesions of mouth), dermatitis

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14
Q

What is the consequence of pyridoxine deficiency?

A

Depression, confusion, convulsions

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15
Q

What is the consequence of nicotinic acid deficiency?

A

Pellagra (dermatitis, depression, diarrhea)

16
Q

How does biotin work?

A

Activates and transfers CO2 during thiol ester formation using CoA

17
Q

What type of enzyme is lactate dehydrogenase?

A

Oxidoreductase, does oxidation-reduction

18
Q

What type of enzyme is chymotrypsin?

A

Hydrolase, transfers functional groups to water

19
Q

How does a glucose-6-phosphate dehydrogenase mutation lead to anemia?

A

Makes less temperature stable; required to make NADPH as substrate for glutathione reductase. Reduced GSH reacts with ROS. Without it, peroxides react with unsaturated FAs in RBC membrane and destroy them.

Biochemistry (17 decks)

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