Block 1

Question 0

Opsonins.

Answer 0

IgG
C3b
C-reactive protein
MBL

Question 1

What conditions are psammoma bodies found in?

Answer 1

Meningioma

Papillary carcinoma of thyroid and ovary

Question 2

LAD1.

Answer 2

AR
Deficiency of beta2 integrins
Recurrent bacterial infection and poor wound healing
Delayed separation of the umbilical cord

Rolling of leukocytes is unaffected

Question 3

LAD 2.

Answer 3

Deficiency of selectin
Poor wound healing
Delayed separation of umbilical cord

Problems with rolling of leukocytes

Question 4

Chediak-Higashi syndrome.

Answer 4

Defect in phagolysosome fusion
Prone to S. aureus and other infections
Neutrophils show giant, fused granules

Melanocytes abnormalities (partial oculocutaneous albinism and silvery hair)
Bleeding disorders
Death in childhood

Question 5

Chronic granulomatous disease.

Answer 5

X-linked recessive
NADPH oxidase mutation
Absence of respiratory burst
Low superoxide production

Question 6

PGE2.

Answer 6

Vasodilation, pain, fever

Question 7

PGE2 alpha.

Answer 7

Contraction of uterine and bronchial muscle

Question 8

PGI2 (prostacyclin).

Answer 8

Vasodilation

Inhibitor of platelet aggregation

Question 9

TXA2 (thromboxane).

Answer 9

Vasoconstriction
Platelet aggregation
Bronchoconstriction

Question 10

Leukotrienes.

Answer 10

Chemoattractant for leukocyte produced by leukocytes
LTB4 - activator of neutrophils
LTE4 - vasoconstriction, bronchospasm, increased vascular permeability
LTC4
LTD4

Question 11

Lipoxins.

Answer 11

Inhibitors of inflammation

Inhibits neutrophils and leukocytes

Question 12

Nitric oxide.

Answer 12

Recruits neutrophils
Inhibition of mast cell induced inflammation
Potent vasodilator
Reduces platelet aggregation and adhesion

Question 13

PAF.

Answer 13

Vasoconstriction
Bronchoconstriction
Leukocyte adhesion
Chemotaxis

Question 14

Vasodilation.

Answer 14

Prostaglandins
Histamine
NO

Question 15

Increase vascular permeability.

Answer 15

Vasoactive amines
C3a and C5a
Bradykinin
Leukotrienes C4, D4, and E4
PAF
Substance P

Question 16

Fever.

Answer 16

IL1
TNF
PGE2

Question 17

Pain.

Answer 17

PGE2

Bradykinin

Question 18

C-reactive protein.

Answer 18

Involved in necrosis with acute inflammation

Elevated in high risk MI, rheumatoid arthritis, and infections